M cell differentiation based on lympho-epithelial interaction

基于淋巴-上皮相互作用的 M 细胞分化

• 批准号: 20790383
• 负责人: HASE Koji
• 金额: $ 2.75万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790383/
• 关键词: M細胞; パイエル板; 上皮細胞; B細胞; 粘膜免疫; パィエル板; 樹状細胞; CD11c+B細胞

M cells are developed in a course of cell-cell interaction between FAE and certain unidentified immune cells. We found that a unique B-cell subset characterized by CCR6^<hi>CD11c^+ resided in mouse PP.Adoptive transfer of CCR6^<hi>CD11c^+ B cells from wild-type mice restored the M-cell decrement in CCR6-deficient mice. Collectively, the spatial regulation of CCR6^<hi>CD11c^+ B cells via the CCL20-CCR6 system may play a vital role in M-cell differentiation in mice.

M细胞是FAE与某些未知免疫细胞相互作用的过程。我们发现小鼠pp中存在一种独特的以CCR6^<hi>CD11c^+为特征的B细胞亚群。来自野生型小鼠的CCR6^<hi>CD11c^+ B细胞的继发性转移恢复了CCR6缺陷小鼠的m细胞减少。综上所述，CCL20-CCR6系统对CCR6^<hi>CD11c^+ B细胞的空间调控可能在小鼠m细胞分化中发挥重要作用。

项目成果

A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity.

• DOI: 10.1084/jem.20080698
• 发表时间: 2008-11-24
• 期刊: The Journal of experimental medicine
• 作者: Terashima A;Watarai H;Inoue S;Sekine E;Nakagawa R;Hase K;Iwamura C;Nakajima H;Nakayama T;Taniguchi M
• 通讯作者: Taniguchi M

粘膜免疫系の最前線におけるM細胞依存的抗原取り込み機構の解明

阐明粘膜免疫系统最前沿的 M 细胞依赖性抗原摄取机制

• 发表时间: 2009
• 作者: Terashima A and Hase K;et al.;Hase K;長谷耕二;長谷耕二
• 通讯作者: 長谷耕二

Activation-Induced Cytidine Deaminase Deficiency Causes Organ-Specific Autoimmune Disease

• DOI: 10.1371/journal.pone.0003033
• 发表时间: 2008-08-21
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Hase, Koji;Takahashi, Daisuke;Ohno, Hiroshi
• 通讯作者: Ohno, Hiroshi

New approach for m-cell-specific molecules screening by comprehensive transcriptome analysis.

• DOI: 10.1093/dnares/dsp013
• 发表时间: 2009-08
• 期刊: DNA research : an international journal for rapid publication of reports on genes and genomes
• 作者: Nakato G;Fukuda S;Hase K;Goitsuka R;Cooper MD;Ohno H
• 通讯作者: Ohno H

GP2-dependent antigen transcytosis by M cells initiates mucosal immune response

M 细胞依赖 GP2 的抗原转胞吞作用启动粘膜免疫反应

• 发表时间: 2010
• 作者: Terashima A and Hase K;et al.;Hase K;長谷耕二
• 通讯作者: 長谷耕二