A morphological study on integration of auditory information on inhibitory tectothalamic neurons in the inferior colliculus.

下丘抑制性顶丘脑神经元听觉信息整合的形态学研究。

• 批准号: 22700365
• 负责人: ITO Tetsufumi
• 金额: $ 2.66万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700365/
• 关键词: 神経回路網; 聴覚神経回路; 聴覚; 局所神経回路; ウイルスベクター; GABA; glutamate; 聴覚系; グルタミン酸; 聴覚系神経回路

Information of sound is analyzed in several auditory nuclei in lower brainstem, and re-integrated in the inferior colliculus in the midbrain. Detailed morphological basis on the integration of sound information, however, is poorly known. Large GABAergic neurons, which composeapproximately 10% of inferior collicular neurons and project to the thalamus, receive dense excitatory axosomatic inputs. In this study, we showed that the axosomatic inputs originated from almost all lower auditory nuclei as well as local neurons, suggesting that large GABAergic neurons integrate auditory information. We also have developed viral tracers which are optimal for the study on detailed dendritic morphology of large GABAergic neurons.

声音信息在脑干下部的几个听觉核团中进行分析，并在中脑下丘重新整合。然而，对声音信息整合的详细形态学基础知之甚少。大的GABA能神经元，约占下丘神经元的10%，投射到丘脑，接受密集的兴奋性轴体输入。在这项研究中，我们发现，轴突体的输入来源于几乎所有的下听觉核团以及本地的神经元，这表明大的GABA能神经元整合听觉信息。我们还开发了病毒示踪剂，这是最佳的大GABA能神经元的详细树突形态的研究。

项目成果

The basic circuit of the IC: tectothalamic neurons with different patterns of synaptic organization send different messages to the thalamus.

• DOI: 10.3389/fncir.2012.00048
• 发表时间: 2012
• 期刊: Frontiers in neural circuits
• 影响因子: 3.5
• 作者: Ito T;Oliver DL
• 通讯作者: Oliver DL

Expression of glutamate and inhibitory amino acid vesicular transporters in the rodent auditory brainstem.

• DOI: 10.1002/cne.22521
• 发表时间: 2011-02-01
• 期刊: JOURNAL OF COMPARATIVE NEUROLOGY
• 影响因子: 2.5
• 作者: Ito, Tetsufumi;Bishop, Deborah C.;Oliver, Douglas L.
• 通讯作者: Oliver, Douglas L.

Amygdala kindling induces nestin expression in the leptomeninges of the neocortex

• DOI: 10.1016/j.neures.2012.12.006
• 发表时间: 2013-02
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: Shogo Ninomiya;Shigeyuki Esumi;K. Ohta;T. Fukuda;Tetsufumi Ito;I. Imayoshi;R. Kageyama;T. Ikeda;S. Itohara;N. Tamamaki

下丘大型抑制性ニューロン上での入力の統合,Convergence of Inputs from Multiple Auditory Nuclei on Tectothalamic Inhibitory Neurons.

来自顶盖丘脑抑制神经元上的多个听觉核团的输入的收敛。

• 发表时间: 2012
• 作者: 伊藤 哲史;Douglas L Oliver
• 通讯作者: Douglas L Oliver

下位聴覚神経核からの情報が収束する下丘抑制性細胞

下丘抑制细胞，来自下听核的信息汇聚于此

• 发表时间: 2012
• 作者: 伊藤 哲史;Douglas L Oliver;伊藤 哲史
• 通讯作者: 伊藤 哲史