The basic circuit of the IC: tectothalamic neurons with different patterns of synaptic organization send different messages to the thalamus.
The basic circuit of the IC: tectothalamic neurons with different patterns of synaptic organization send different messages to the thalamus.
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DOI：
10.3389/fncir.2012.00048
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发表时间：
2012
影响因子：
3.5
通讯作者：
Oliver DL
中科院分区：
文献类型：
--
作者：
Ito T;Oliver DL
听觉系统中脑的下丘（IC）使用一个独特的基本电路来组织来自几乎所有下听觉脑干的输入，并将这些信息传递给丘脑的内侧膝状体（MGB）。在这里，我们回顾了IC的基本电路，神经元的类型，它们的输入和输出的组织。我们特别讨论了大GABAergic （LG）神经元以及它们与小GABAergic （SG）和更多的谷氨酸能神经元的区别。LG神经元的体细胞和树突通过轴体细胞谷氨酸能突触来识别，这在其他细胞类型中是缺乏的，并且只含有谷氨酸转运体VGLUT2。虽然LG神经元在IC （ICC）的中央核中数量最多，但对其分布的分析表明，它们并不专门与一组上升输入相关。ICC的输入可能被组织成具有不同脑干输入子集的功能区，但每个功能区可能包含相同的三种神经元类型。然而，LG神经元上VGLUT2轴体细胞末梢的来源尚不清楚。仅表达VGLUT2基因的耳蜗背核、橄榄上复合体、外侧小丘中间核和IC本身的神经元可能是LG丘脑神经元上密集的VGLUT2轴体细胞末梢的起源。IC是独特的，因为LG神经元是gaba能的丘脑神经元，除了众多的谷氨酸能的丘脑神经元。SG神经元明显针对其他听觉结构。IC，特别是LG神经元的基本电路，对声音信息通过中脑传递到MGB有影响。
The inferior colliculus (IC) in the midbrain of the auditory system uses a unique basic circuit to organize the inputs from virtually all of the lower auditory brainstem and transmit this information to the medial geniculate body (MGB) in the thalamus. Here, we review the basic circuit of the IC, the neuronal types, the organization of their inputs and outputs. We specifically discuss the large GABAergic (LG) neurons and how they differ from the small GABAergic (SG) and the more numerous glutamatergic neurons. The somata and dendrites of LG neurons are identified by axosomatic glutamatergic synapses that are lacking in the other cell types and exclusively contain the glutamate transporter VGLUT2. Although LG neurons are most numerous in the central nucleus of the IC (ICC), an analysis of their distribution suggests that they are not specifically associated with one set of ascending inputs. The inputs to ICC may be organized into functional zones with different subsets of brainstem inputs, but each zone may contain the same three neuron types. However, the sources of VGLUT2 axosomatic terminals on the LG neuron are not known. Neurons in the dorsal cochlear nucleus, superior olivary complex, intermediate nucleus of the lateral lemniscus, and IC itself that express the gene for VGLUT2 only are the likely origin of the dense VGLUT2 axosomatic terminals on LG tectothalamic neurons. The IC is unique since LG neurons are GABAergic tectothalamic neurons in addition to the numerous glutamatergic tectothalamic neurons. SG neurons evidently target other auditory structures. The basic circuit of the IC and the LG neurons in particular, has implications for the transmission of information about sound through the midbrain to the MGB.
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DOI：
10.1073/pnas.0907873107
发表时间：
2010-01-05
影响因子：
11.1
作者：
Lee, Charles C.;Sherman, S. Murray
通讯作者：
Sherman, S. Murray
影响因子：
2.5
作者：
MALMIERCA, MS;BLACKSTAD, TW;MOLOWNY, RL
通讯作者：
MOLOWNY, RL
影响因子：
3.3
作者：
OLIVER, DL
通讯作者：
OLIVER, DL
影响因子：
2.9
作者：
Ito, Tetsufumi;Oliver, Douglas L.
通讯作者：
Oliver, Douglas L.
影响因子：
2.8
作者：
Chernock, ML;Larue, DT;Winer, JA
通讯作者：
Winer, JA