The interaction between respiratory and cardiovascular regulations during exercise

运动过程中呼吸和心血管调节之间的相互作用

基本信息

批准号：
22700649
负责人：
KATAYAMA Keisho
金额：
$ 2.66万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2011
项目状态：
已结题

项目摘要

The purpose of the present study was to elucidate 1) whether carotid chemoreceptors affects muscle sympathetic nerve activity and cardiovascular responses during exercise, and 2) the influence of inspiratory muscle fatigue on muscle sympathetic nerve activity and blood pressure.Study 1 : Muscle sympathetic nerve activity(MSNA), cardiovascular variables, and plasma norepinephrine(NE) concentrations were measured during leg cycling at 40% and 60% of peak oxygen uptake(V. O2_<peak>) while breathing hypoxic gas mixture. MSNA during exercise in hypoxia was higher than in normoxia. These results suggest that acute hypoxia augments muscle neural activation during dynamic leg exercise, and that the MSNA response during exercise in hypoxia could be different from the change in plasma NE concentrations.Study 2 : MSNA and cardiovascular parameters were recorded during dynamic leg cycling at 40% V. O2_<peak> with or without inspiratory resistive breathing. The time-dependent increase in MSNA appeared during exercise with inspiratory resistive breathing, accompanied by an augmentation of blood pressure(BP). These results suggest that inspiratory muscle fatigue induces increases in muscle sympathetic vasomotor ouflow and BP during dynamic exercise.

The purpose of the present study was to elucidate 1) whether carotid chemoreceptors affects muscle sympathetic nerve activity and cardiovascular responses during exercise, and 2) the influence of inspiratory muscle fatigue on muscle sympathetic nerve activity and blood pressure.Study 1 : Muscle sympathetic nerve activity(MSNA), cardiovascular variables, and plasma norepinephrine(NE) concentrations were measured during leg在呼吸低氧气体混合物时，以40％和60％的峰值氧气摄取（v。O2_<peak>）循环。在运动中运动过程中的MSNA高于常氧。这些结果表明，急性缺氧在动态腿部运动过程中增加了肌肉神经激活，并且在运动中运动过程中的MSNA反应可能与血浆NE浓度的变化不同。研究2：MSNA和心血管参数在40％V。O2_<peacs n 40％V>中，具有或无灵感的breusive Breatherthertions在40％V>时记录了动态腿部循环。在运动过程中，MSNA的时间依赖性增加出现，并伴有增强血压（BP）。这些结果表明，在动态运动过程中，吸气性肌肉疲劳会诱导肌肉交感神经X肌舒张器OUFLOW和BP的增加。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Inspiratory muscle fatigue increases sympathetic vasomotor outflow and blood pressure during submaximal exercise

DOI：
10.1152/ajpregu.00006.2012
发表时间：
2012-05-01
期刊：
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
影响因子：
2.8
作者：
Katayama, Keisho;Iwamoto, Erika;Saito, Mitsuru
通讯作者：
Saito, Mitsuru

Muscle Deoxygenation during Sustained and Intermittent Isometric Exercise in Hypoxia