Is exercise-induced prevention of depression dependent on hepatic VEGF formation via HIF-1α
Is exercise-induced prevention of depression dependent on hepatic VEGF formation via HIF-1α
运动诱发的抑郁症预防是否依赖于通过 HIF-1α 形成肝脏 VEGF
批准号：
22700661
负责人：
NAKAJIMA Sanae
金额：
$2.58万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
中文摘要
翻译
本研究旨在探讨运动诱导的海马神经发生增强和抑郁症的预防是否与海马依赖于肝脏VEGF的VEGF信号通路有关。前期研究结果提示，定期运动可通过海马血管内皮生长因子信号通路预防应激性抑郁的发生，而不依赖于运动诱导的肝脏血管内皮生长因子的升高。
英文摘要
The purpose of this study was to investigate whether exercise-induced enhancement of hippocampal neurogenesis and prevention of depression is attributed to VEGF signaling pathway of hippocampus dependently on hepatic VEGF. The preset findings suggested that regular exercise prevents stress-induced onset of depression via VEGF signaling pathway of hippocampus independently of exercise-induced increase of hepatic VEGF.
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