Is exercise-induced prevention of depression dependent on hepatic VEGF formation via HIF-1α

运动诱发的抑郁症预防是否依赖于通过 HIF-1α 形成肝脏 VEGF

• 批准号: 22700661
• 负责人: NAKAJIMA Sanae
• 金额: $ 2.58万
• 依托单位: Kyoritsu Women's Junior College (2011)Nippon Medical School (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700661/
• 关键词: 運動; 神経新生; 海馬; ストレス; 血管新生; VEGF

The purpose of this study was to investigate whether exercise-induced enhancement of hippocampal neurogenesis and prevention of depression is attributed to VEGF signaling pathway of hippocampus dependently on hepatic VEGF. The preset findings suggested that regular exercise prevents stress-induced onset of depression via VEGF signaling pathway of hippocampus independently of exercise-induced increase of hepatic VEGF.

本研究的目的是探讨运动诱导的海马神经发生的增强和抑郁症的预防是否归因于依赖于肝脏VEGF的海马VEGF信号通路。本研究结果提示，规律运动通过海马VEGF信号通路预防应激诱导的抑郁发作，而不依赖于运动诱导的肝脏VEGF的增加。