Association between plasticity of adipose tissue and expression of adrenergic receptor and glucocorticoid receptor

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We studied the effects of clenbuterol(CLE) and dexamethasone(DEX)(each dose=1mg/kg body weight per day for 10 days) on the mRNA expressions ofβ_1-,β_2-andβ_3-adrenergic receptor(AR), glucocorticoid receptor and uncoupling protein(UCP)-1, 2 and 3 in periepididymal(PED), perirenal(PRE) and brown adipose tissues. CLE significantly decreased the relative weight of PED and PRE adipose tissues per body weight without changing that of brown adipose tissue. On the other hand, DEX increased the relative weight of PED and brown adipose tissues per body weight, and decreased that of PRE adipose tissue per body weight. These results suggest that the effects of CLE and DEX on the mRNA expressions ofβ-ARs, GR, and UCPs and adipose tissue mass depend on the type of adipose tissues.