The institution of reference nutrient intake on phosphate, aimed prevention for the lifestyle-related disease

制定磷酸盐参考营养素摄入量，旨在预防生活方式相关疾病

• 批准号: 22700750
• 负责人: SHUTO Emi
• 金额: $ 2.58万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700750/
• 关键词: 生活習慣病; 慢性炎症; 動脈硬化; 高リン血症; リン; 心血管疾患; 酸化ストレス

Excessive dietary phosphorus(P) has been speculated as a risk factor for cardiovascular disease(CVD) in healthy persons as well as in patients with chronic kidney disease. We reported that high P-loading increased production of reactive oxygen species and decrease nitric oxide(NO) availability in endothelial cells. In addition, we performed dose and time-dependent effect of dietary P intake on endothelial function in healthy male volunteers. High P meals significantly increased serum P levels in a dose-dependent manner, whereas significant decrease in% flow-mediated dilation(% FMD) was observed. Significant negative correlation was also observed between% FMD and serum P. These results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people. Habitual excessive P intake and resulting in endothelial dysfunction may contribute to progress CVD or increasing mortality as epidemiologically speculated.

膳食中磷(P)过量已被推测为健康人以及慢性肾脏疾病患者心血管疾病（CVD）的危险因素。我们报道了高磷负荷增加了活性氧的产生，降低了内皮细胞中一氧化氮（NO）的可用性。此外，我们还研究了膳食P摄入量对健康男性志愿者内皮功能的剂量和时间依赖性效应。高磷膳食以剂量依赖性方式显著提高血清磷水平，而血流介导的舒张率（% FMD）显著降低。FMD与血清P呈显著负相关，提示过量膳食P可严重损害健康人的内皮功能。正如流行病学推测的那样，习惯性过量摄入P并导致内皮功能障碍可能有助于心血管疾病的进展或增加死亡率。

项目成果

Dietary deoxynucleic acid induces type 2 T-helper immune response through toll-like receptor 9 in mice

膳食脱氧核酸通过小鼠中的 Toll 样受体 9 诱导 2 型 T 辅助免疫反应

• 发表时间: 2010
• 期刊: Eur J Nutr.2010 Dec 4
• 作者: Nakamoto M;et al
• 通讯作者: et al