The elucidation of the effect of T-cell and mechanism of metabolic syndrome by dietary composition

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Metabolic syndrome is the underlying disease proceed crirical disorder, diabetes, stroke, et al. Nearly, it was reported that T cell-infiltrated in adipose tissues was regulated differentiation of macrophage, so macrophage was dictated chronic inflammation in adipose tissue and whole-body. We ever reported about immune function of soy isoflavone. In this study, we examined effect of Soy isoflavones on the inflammation in diet indused obesity mice.Soy isoflavones were ameliorated glucose metabolism and lipid metabolism, and declining trend to accumulation of body fat. In particular, Equol was significantly inhibited expression of gene associated macrophage. Thus, it is suggested that soy isoflavone might be possible to prevent metabolic syndrome.