Development of the cell morphology database for drug and bioprobe discovery

点击翻译按钮获取中文摘要

To discover small drug like molecules, we have constructed the encyclopedia of cellular morphology, consisting of the cell-shape changes induced by various compounds. Particularly, we have developed high-content image analysis method to examine the effect of～ 100 routinely used chemicals on the cell morphology accompanied by statistical characterization of the obtained phenotypic data. We demonstrated the cell morphology-based profiling system not only reproduces "drug-target-phenotype" relationships for a series of drugs with known targets but also raises the possibility to clear the way to discovery of unique drug candidates.