Studies to assess the neural basis of constraint-induced movement therapy (CIMT) which is intensive therapy for hemiparetic upper extremities in stroke patients: diffusion tensor imaging studies

评估约束诱导运动疗法（CIMT）的神经基础的研究，CIMT 是中风患者偏瘫上肢的强化疗法：弥散张量成像研究

• 批准号: 23300203
• 负责人: DOMEN Kazuhisa
• 金额: $ 11.23万
• 依托单位: Hyogo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23300203/
• 关键词: CI療法; 脳卒中; 拡散テンソル画像; 予後予測; 運動学習; ニューロリハビリテーション; 片麻痺; 上肢機能; 学習性不使用; 可塑性

To test whether diffusion tensor imaging could evaluate potential motor capability of patients with chronic cerebral infarction. We used constraint-induced movement therapy (CIMT) as a rehabilitation, which reveals potential motor capability. We also investigated the relationship between the outcome of CIMT and the ratio between fractional anisotropy values (rFA) in affected and unaffected sites of the corticospinal tract before CIMT. Imaging was performed in cerebral infarction patients and the rFA of the posterior limb of internal capsule (PLIC) was measured before CIMT. Patients were evaluated before and after CIMT using the Fugl-Meyer (F-M) assessment,Wolf Motor Function Test, and Motor Activity Log. All patients showed an improvement in mobility following the 10-day CIMT session. Strong positive correlation was found only between F-M after CIMT and PLIC-rFA (r = 0.8098, p = 0.0004).These data support PLIC-rFA as a new marker of the CIMT-induced improvement in motor function.

目的探讨弥散张量成像对慢性脑梗死患者潜在运动能力的评价。我们使用约束诱导运动疗法（CIMT）作为一种康复，揭示了潜在的运动能力。我们还研究了CIMT结果与CIMT前皮质脊髓束受影响部位和未受影响部位的分数各向异性值（rFA）之比之间的关系。对脑梗死患者行影像学检查，并在CIMT前测量内囊后肢rFA。患者在CIMT前后使用Fugl-Meyer （F-M）评估、Wolf运动功能测试和运动活动日志进行评估。所有患者在为期10天的CIMT治疗后均表现出活动能力的改善。仅CIMT后F-M与PLIC-rFA呈正相关（r = 0.8098, p = 0.0004）。这些数据支持PLIC-rFA作为cimt诱导的运动功能改善的新标志物。

项目成果

Relationship between diffusion tensor fractional anisotropy and motor outcome in patients with hemiparesis after corona radiata infarct

放射冠梗塞后偏瘫患者弥散张量各向异性分数与运动结局的关系

• DOI: 10.1016/j.jstrokecerebrovasdis.2013.02.017
• 发表时间: 2013
• 期刊: J Stroke Cerebrovasc Dis
• 作者: Koyama T;Marumoto K;Miyake H;Domen K
• 通讯作者: Domen K

MRI拡散テンソル法（DTI） FA値と脳梗塞片麻痺症状の関連

MRI弥散张量法（DTI）FA值与脑梗死偏瘫症状的关系

• 发表时间: 2013
• 作者: 小山 哲男;丸本 浩平;道免 和久
• 通讯作者: 道免 和久

Diffusion Tensor Imaging (DTI)を使用した慢性期脳梗塞患者のlearned nonuseの評価

使用弥散张量成像 (DTI) 评估慢性脑梗死患者的习得性不使用

• 发表时间: 2012
• 作者: Nagai A;Hattori T;Nozaki K;Aizawa M;Yamashita K.;丸本 浩平
• 通讯作者: 丸本 浩平

Constraint-induced movement therapy(CI 療法)の拡散テンソル画像による神経基盤研究

使用扩散张量成像进行约束诱导运动治疗（CI 治疗）的神经基础研究

• 发表时间: 2011
• 作者: Rong R;Ito O;Mori N;Tamura Y;Mori T;Ito S;Totsune K;Takahashi K;Kohzuki M;丸本浩平
• 通讯作者: 丸本浩平

Relationship between diffusion-tensor fractional anisotropy and long-term outcome in patients with hemiparesis after intracerebral hemorrhage

弥散张量各向异性分数与脑出血后偏瘫患者远期预后的关系

• DOI: 10.3233/nre-130825
• 发表时间: 2013
• 期刊: NeuroRehabilitation
• 影响因子: 2
• 作者: Koyama T;Marumoto K;Miyake H;Ohmura T;Domen K
• 通讯作者: Domen K