Mechanism of sex-related difference and its toxicological significance in the toxic manifestation of inorganic arsenic

无机砷毒性表现的性别差异机制及其毒理学意义

• 批准号: 23310045
• 负责人: WATANABE Chiho
• 金额: $ 12.65万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23310045/
• 关键词: 人体有害物質; 無機砒素; 毒性への感受性; 遺伝子多型; セレン; 性差; フィールド調査; 実験研究; ヒ素曝露; メチル化代謝; ネパール; バングラデシュ; 国際研究者交流; マウス; 酸化ストレス; 砒素汚染地域; ヒ素汚染地域

Population at health risk posed by exposure to inorganic arsenic in the groundwater is estimated to be more than 50 million in the world. One of the striking features of inorganic arsenic toxicity is its distinct inter-individual and inter-population variation, which is associated with sex, genetic characteristics, and nutrition. We hypothesized that the effects of all of these susceptibility-associated factors can be ascribable to the difference in arsenic metabolism, and tried to prove this using both field survey and experimental approach. In the field we have conducted survey in three arsenic-contamination sites in South Asia. Major findings included that sex-associated difference in toxic manifestation of arsenic depended on the outcome that we are observing, and that the proportion of the most toxic metabolites (MMA) showed negative correlation with the concentration of selenium.

据估计，全世界有5000多万人因接触地下水中的无机砷而面临健康风险。无机砷毒性的显著特征之一是其明显的个体间和种群间变异，这种变异与性别、遗传特征和营养有关。我们假设所有这些易感相关因素的影响可以归因于砷代谢的差异，并试图通过现场调查和实验方法来证明这一点。在实地，我们在南亚的三个砷污染点进行了调查。主要发现包括砷中毒表现的性别差异取决于我们观察的结果，最有毒代谢物(MMA)的比例与硒浓度呈负相关。

项目成果

The Role of Gender in Inorganic Arsenic Induced Oxidative Stress Among Bangladeshi Population Exposed to High Arsenic Through Drinking Water

性别在通过饮用水接触高砷的孟加拉国人口中无机砷引起的氧化应激中的作用

• 发表时间: 2011
• 作者: Nayar Sultana;Chiho Watanabe;Hana Furusawa;Masahiro Umezaki;Tsukasa Inaoka
• 通讯作者: Tsukasa Inaoka

バングラデシュのヒ素汚染地域住民における血漿中・尿中のヒ素およびセレン濃度の関連

孟加拉国砷污染地区居民血浆和尿砷、硒浓度的关系

• 发表时间: 2013
• 作者: 徐子牛;白石一乗;児玉靖司;松野佑真 古澤華 稲岡司 渡辺知保
• 通讯作者: 松野佑真 古澤華 稲岡司 渡辺知保

Arsenic exposure increases maternal but not cord serum immunoglobulin G level

砷暴露会增加母体血清免疫球蛋白 G 水平，但不会增加脐带血清免疫球蛋白 G 水平

• 发表时间: 2014
• 期刊: Bangladesh Pediatrics International
• 作者: Ping Han Ser;Bilkis Banu;Fatema Jebunnesa;Kaneez Fatema;Nasrin Rosy;Rabeya Yasmin;Hana Furusawa;Liaquat Ali;Akhtar Ahmad;Chiho Watanabe;PhD
• 通讯作者: PhD

Effects of Arsenic on Expressions of Ube2d Family and Accumulation of p53 in Renal Tubular Cells and Vascular Endothelial Cells

砷对肾小管细胞和血管内皮细胞Ube2d家族表达及p53积累的影响

• 发表时间: 2013
• 作者: Satoh M.;Lee J.Y.;Tokumoto M.;Fujiwara Y.;Watanabe C
• 通讯作者: Watanabe C

Inorganic Arsenic-induced Oxidative Stress among Bangladeshi Population Exposed to High Arsenic Through Drinking Water

通过饮用水接触高砷的孟加拉国人口中无机砷引起的氧化应激

• 发表时间: 2012
• 作者: 高田秀重;田中厚資;青木千佳子;市川馨子;山下麗;Sultana N
• 通讯作者: Sultana N