Study on Molecular Mechanism of Cytotoxicity of Marine Natural Products

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The molecular mechanism of antitumor activity of aplyronine A, a marine macrolide, has been investigated. Using chemical probes aplyronine A was found to bind to actin and tubulin to form a ternary complex.As a result, aplyronine A inhibits tubulin polymerization, induces irregular, multipolar spindle structures, inhibits cell-cycle progression in M-phase, and induces apoptosis.Total synthesis of biselide A, a cytotoxic marine macrolide, was achieved by using Wittig reaction and sereoselective enzymatic hydrolysis of allylic alcohol as key steps.