Study on novel modes of action of antitumor marine natural products

生物有机研究的新模式的抗肿瘤/cytotoxic活性的aacronine A，aurilide，和haterumalides的影响。合成了一个新的杂合类似物，并对其生物活性进行了评价。金内酯的靶生物分子被鉴定为线粒体蛋白抑制素，其稳定线粒体的管状结构。Aurilide与probititin结合，导致线粒体碎裂。合成了异丙酰亚胺类似物，并对其细胞毒性进行了评价。

Bioorganic studies on novel modes of antitumor/cytototic activities of aplyronine A, aurilide, and haterumalides are effected. A hybrid analog between aplyronine A and mycalolide B was synthesized, and its bioactivities were evaluated. Target biomolecule of aurilide was identified to be prohibitin, a mitochondrial protein, which stabilized the tubular structure of mitochondria. Aurilide binds to probititin, which resulted in the fragmentation of mitochondoria. Analogs of haterumalides were synthesized, and their cytotoxicity was evaluated.