Novel Thiourea-Based Bifunctional Organocatalysts and Their Applications in Asymmetric Catalysis

新型硫脲基双功能有机催化剂及其在不对称催化中的应用

• 批准号: 54022237
• 负责人: Professor Dr. Albrecht Berkessel
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/54022237?language=en
• 关键词: Novel; Thiourea; Based; Bifunctional; Organocatalysts

Enantiomerically pure organic compounds are gaining continuously in importance. For example, more and more optically active Pharmaceuticals are introduced to the market, either as new drugs or as the result of a "racemic switch". Therefore, the development of asymmetric reactions that afford optically active compounds from simple and readily available reagents has been of ongoing interests over the past decade(s). Apart from metal-based asymmetric catalysis, small organic molecules-catalyzed enantioselective transformations have received increasing attention over the past years. In particular, organocatalysts bearing a thiourea (or urea) group are the subjects of intensive research. The double hydrogen-bonding interaction of the thiourea (or urea) NHs and the reactant has been generally realized to play the central role in (thio)urea-based catalysis. The incorporation of a second functional group has been another leap forward with regard to the scope of reactions amenable to (thio)urea catalysis. Great progress has been made in the design and applications of e.g. bifunctional thiourea-amine, or thiourea-alcohol catalysts.

对映体纯的有机化合物越来越重要。例如，越来越多的光学活性药物作为新药或作为“外消旋转换”的结果被引入市场。因此，在过去的十年中，从简单且容易获得的试剂提供光学活性化合物的不对称反应的开发一直受到关注。近年来，除了金属不对称催化外，有机小分子催化的不对称转化反应也越来越受到人们的关注。特别地，带有硫脲（或脲）基团的有机催化剂是深入研究的主题。硫脲（或脲）NHs与反应物之间的双氢键相互作用在硫脲基催化反应中起着重要作用。第二官能团的引入是关于适合于（硫）脲催化的反应范围的另一个飞跃。在双功能硫脲-胺或硫脲-醇催化剂的设计和应用方面已经取得了很大进展。