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Precise Characterization of Macromolecular Assemblies for Quality Control of Biomaterials

Precise Characterization of Macromolecular Assemblies for Quality Control of Biomaterials
用于生物材料质量控制的大分子组装体的精确表征
批准号:
23350055
负责人:
SATO Takahiro
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-11-18 至 2014-03-31

项目摘要

项目成果

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中文摘要
翻译
大分子组件被用作药物递送系统、纳米载体或生物传感器等生物材料。大分子组装体的精确表征对于控制这些生物材料的质量至关重要。在这项研究中,我们建立了表征溶液中热敏嵌段共聚物和多电解质配合物的方法。所研究的三种热敏嵌段共聚物均发生了同时胶束化和相分离,均为弱分离的弱两亲性嵌段共聚物。用小角x射线散射对溶液中的胶束和浓相液滴进行了表征。采用静态光散射法和电泳光散射法测定了水溶液中两种聚阴离子和两种聚阳离子的四种组合的聚电解质复合物的净电荷数和总电荷数(或聚集数),并与所提出的复合物形成机制进行了比较。
英文摘要
Macromolecular assemblies are utilized as biomaterials like drug delivery system, nano-carrier, or bio-sensor. Precise characterization of macromolecular assemblies is essential to control the quality of those biomaterials. In this study, we have established the method for characterizing assemblies of thermoresponsive block copolymers and polyelectrolyte complexes in solution. Simultaneous micellization and phase separation took place in three thermoresponsive block copolymers investigated, all of which were weakly segregated and weakly amphiphilic block copolymers. Both micelles and concentrated-phase droplets in the solutions were characterized by small-angle X-ray scattering. The number of net charges and total charges (or the aggregation number) per the polyelectrolyte complex were determined by static and electrophoretic light scattering methods for four combinations of two polyanions and two polycations in aqueous solution to compare with proposed complex formation mechanism.
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会议论文
フマルアミド誘導体とN-イソプロピルアクリルアミド共重合体水溶液の相挙動
富马酰胺衍生物与N-异丙基丙烯酰胺共聚物水溶液的相行为
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [松元亜紀子, 橋爪章仁, 佐藤尚弘]
通讯作者: 佐藤尚弘
Double Screw-Sense Inversions of Helical Chiral-Achiral Random Copolymers of Fluorene Derivatives in Phase Separating Solutions
相分离溶液中芴衍生物螺旋手性-非手性无规共聚物的双螺旋反转
DOI: --
发表时间: 2011
期刊: Polym.J
影响因子: --
作者: [Yusuke Sanada, Ken Terao, and Takahiro Sato]
通讯作者: and Takahiro Sato
水溶液中における一本鎖DNAの分子形態と会合挙動
单链DNA在水溶液中的分子形态和缔合行为
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Masahiko Ohta, Kenta Kokado, Kazuki Sada, 山村 浩樹,玉田 佳子,寺尾 憲,佐藤尚弘]
通讯作者: 山村 浩樹,玉田 佳子,寺尾 憲,佐藤尚弘
溶液中での高分子集合体の構造解析
溶液中聚合物聚集体的结构分析
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [H. Okamoto, M. Yamaji, S. Gohda, K. Sato, H. Sugino and K. Satake, 南部貴則・中村香澄・小門憲太・佐田和己, 佐藤尚弘]
通讯作者: 佐藤尚弘
共 56 条
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