Studies on the development of anti-obesity synbiotics

我们之前发现植物乳杆菌14号可以减少小鼠的肥胖，但其细胞和分子机制尚不清楚。目前的研究表明，植物乳杆菌14号可以减轻2型糖尿病小鼠的肥胖、脂肪组织炎症和胰岛素抵抗。此外，我们还发现，从饲喂植物乳杆菌14号的小鼠血清中分离出的外切体可以减少腹膜渗出细胞和小鼠巨噬细胞系RAW264.7中炎性细胞因子的产生。这些结果表明，外切体在植物乳杆菌14号的抗炎作用中起着细胞间通讯的作用。

We previously showed that Lactobacillus plantarum No.14 reduces obesity in mice, whereas the cellular and molecular mechanisms remain unknown. The present study demonstrated that L. plantarum No.14 reduces obesity, adiopose tissue inflammation, and insulin resistance in type 2 deiabetic mice. In addition, we showed that exosomes isolated from the serum of mice fed L. plantarum No.14 reduce the production of inflammatory cytokines in peritoneal exudate cells and murine macrophage cell line RAW264.7. The results suggest that exosomes play a role in cell-to-cell communication in terms of anti-inflammatory action of L. plantarum No.14.