Elucidation of recognition and response of intestinal immune cells to microbes in relation to development of immunomodulating functional foods

阐明肠道免疫细胞对微生物的识别和反应与免疫调节功能食品的开发相关

• 批准号: 23380073
• 负责人: HACHIMURA SATOSHI
• 金额: $ 11.98万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23380073/
• 关键词: 腸管免疫系; 腸内共生菌; 機能性食品; IgA抗体; TLR; 制御性T細胞; 樹状細胞; 経口免疫寛容; 制御性Ｔ細胞; 感染防御

In this study, we tried to elucidate the functions of intestinal immune cells, focusing on their responses to microbes and microbial components, in relation to development of novel immunomodulating functional foods. We examined the suppressive response of Peyer's patch dendritic cells to multiple TLR simulation. We analyzed CD3-IL-2R+ cells, and found that they were also present in the lungs, and that they responded to influenza virus infection. We also examined gene expression of regulatory T cells induced in oral tolerance. Furthermore, we examined the mechanism of IgA induction by Bacteroides.

在这项研究中，我们试图阐明肠道免疫细胞的功能，重点是它们对微生物和微生物组分的反应，与开发新型免疫调节功能食品有关。我们研究了派尔集合淋巴结树突状细胞对多重TLR模拟的抑制反应。我们分析了CD 3-IL-2 R+细胞，发现它们也存在于肺中，并且它们对流感病毒感染有反应。我们还检查了口服耐受诱导的调节性T细胞的基因表达。此外，我们还研究了拟杆菌诱导伊加的机制。

项目成果

Commensal bacteria promote migration of mast cells into the intestine

• DOI: 10.1016/j.imbio.2010.10.007
• 发表时间: 2011-06-01
• 期刊: IMMUNOBIOLOGY
• 影响因子: 2.8
• 作者: Kunii, Junichi;Takahashi, Kyoko;Kaminogawa, Shuichi
• 通讯作者: Kaminogawa, Shuichi

Transcription of the Tollip gene is elevated in intestinal epithelial cells through impaired O-GlcNAcylation-dependent nuclear translocation of the negative regulator Elf-1.

Tollip 基因的转录在肠上皮细胞中通过负调节因子 Elf-1 的 O-GlcNAcNA 酰基化依赖性核易位受损而升高。

• 发表时间: 2011
• 期刊: Biochemical and Biophysical Research Communications - BBRC
• 作者: Yutaka Sugi;Kyoko Takahashi;K. Nakano;A. Hosono;S. Kaminogawa
• 通讯作者: S. Kaminogawa

Attenuation of migration properties of CD4+ T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid and RALDH expression compared to young mice.

与年轻小鼠相比，老年小鼠 CD4 T 细胞迁移特性的减弱与趋化因子受体表达、对视黄酸的反应和 RALDH 表达的降低相关。

• DOI: 10.1080/09168451.2014.910099
• 发表时间: 2014
• 期刊: Biosci. Biotechnol. Biochem.
• 作者: Jihyun Park;Takuya Miyakawa;Aya Shiokawa;Haruyo Nakajima-Adachi;Masaru Tanokura;Satoshi Hachimura
• 通讯作者: Satoshi Hachimura

Gut as a target for functional food

• DOI: 10.1016/j.tifs.2011.06.002
• 发表时间: 2011-12-01
• 期刊: TRENDS IN FOOD SCIENCE & TECHNOLOGY
• 影响因子: 15.3
• 作者: Shimizu, Makoto;Hachimura, Satoshi
• 通讯作者: Hachimura, Satoshi

腸内共生菌のIgA産生に関わる免疫担当細胞に対する作用

肠道共生菌对参与 IgA 产生的免疫活性细胞的影响

• 发表时间: 2011
• 作者: 石井俊祐;八村敏志;輪島隼一;小川晋平;高橋宜聖;高橋恭子;細野朗;上野川修一
• 通讯作者: 上野川修一