Protectivity of extensive infections by a bacterial outer membrane protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

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Protective effects of an outer membrane protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from a bacterium Edwardsiella tarada against other difficult fish diseases, pseudotuberculosis and nocardiosis, was investigated using yellowtail (Seriola quinqueradiata). The fish immunized with GAPDH did not show enough level of protection against both diseases. However, it showed the growth inhibition of infecting Nocardia inside fish body, increased the production of immunoglobulin, and stimulated some immuno-competent genes. Fish pathogenic Mycobacterium sp. was found to be a model bacterium that may show pathogenicity to humans.