Anti-obesity activity of siphonaxanthin, a unique carotenoid in green algae, and its mechanism.

绿藻中独特的类胡萝卜素虹黄素的抗肥胖活性及其机制。

• 批准号: 23380124
• 负责人: TAKASHI HIRATA
• 金额: $ 12.15万
• 依托单位: Shijonawate Gakuen University (2013)Kyoto University (2011-2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23380124/
• 关键词: カロテノイド; 緑藻; 肥満; 脂肪細胞; シフォナキサンチン; 食品機能性; 抗肥満作用; 血管新生

Siphonaxanthin is a specific carotenoid found in siphonaceous green algae and its bio-functional properties are yet to be studied. In this regard, we focused on elucidating the anti-obesity effect of siphonaxanthin. Siphonaxanthin potently inhibited the differentiation of 3T3-L1 preadipocytes. In addition, mRNA expression of adipogenic genes was decreased by the treatment with siphonaxanthin. In the animal study using KK-Ay mice as obesity model, abdominal white adipose tissue was decreased by oral administration of siphonaxanthin. In this case, mRNA expression of lipogenic genes was suppressed and lipolytic genes were increased in siphonaxanthin-treated mice.These findings suggest that siphonaxanthin could be potentially useful as a nutraceutical.

管黄素是一种在虹吸绿藻中发现的特殊类胡萝卜素，其生物功能特性尚待研究。对此，我们重点阐明了虹黄素的抗肥胖作用。 Siphonaxanthin 有效抑制 3T3-L1 前脂肪细胞的分化。此外，用管黄素处理可降低脂肪形成基因的 mRNA 表达。在使用KK-Ay小鼠作为肥胖模型的动物研究中，口服管黄素可减少腹部白色脂肪组织。在这种情况下，在管黄素处理的小鼠中，脂肪生成基因的 mRNA 表达受到抑制，脂肪分解基因增加。这些发现表明，管黄素可能作为一种营养保健品有用。

项目成果

Marine algal carotenoids inhibit angiogenesis by down-regulating FGF-2-mediated intracellular signals in vascular endothelial cells

• DOI: 10.1007/s11010-013-1651-5
• 发表时间: 2013-08-01
• 期刊: MOLECULAR AND CELLULAR BIOCHEMISTRY
• 影响因子: 4.3
• 作者: Ganesan, Ponesakki;Matsubara, Kiminori;Hirata, Takashi
• 通讯作者: Hirata, Takashi

海藻カロテノイドによる血管新生抑制作用の分子機構

海藻类胡萝卜素抑制血管生成的分子机制

• 发表时间: 2012
• 作者: Ganesan;P.;松原主典;菅原達也;平田孝
• 通讯作者: 平田孝

Evaluation on the anti-angiogenic activity of marine algal carotenoids

海藻类胡萝卜素抗血管生成活性评价

• 发表时间: 2011
• 作者: Ponasakki Ganasan;Kiminori Matsubara;Takeshi Okubo;Yukihisa Tanaka;Tatsuya Sugawara;Takashi Hirata
• 通讯作者: Takashi Hirata

海藻カロテノイドによる血管新生抑制の作用機構

海藻类胡萝卜素抑制血管生成的作用机制

• 发表时间: 2011
• 作者: Ponesakki Ganesan;菅原達也;松原主典;平田孝
• 通讯作者: 平田孝

Siphonaxanthin, a green algal carotenoid, as a novel functional compound.

• DOI: 10.3390/md12063660
• 发表时间: 2014-06-19
• 期刊: Marine drugs
• 影响因子: 5.4
• 作者: Sugawara T;Ganesan P;Li Z;Manabe Y;Hirata T
• 通讯作者: Hirata T