Proteomic and metabolomic analysis on chemo-sensitivity and resistance of cancer towards personalized medicine

癌症药物治疗疗效的患者间差异是改善癌症治疗的最大障碍之一。本研究探讨了化疗药物药理作用的细胞机制和肿瘤对药物作用的耐药机制。我们使用的方法是最新的蛋白质组学和代谢组学分析，测量细胞内丰富的蛋白质和代谢物的表达。基于综合代谢组学指纹图谱和蛋白质表达分析，我们发现了几种与癌症化学敏感性或耐药相关的新蛋白质和代谢物。这些发现有望导致开发一种新的个性化癌症药物疗法。

Inter-patient variability in the efficacy of cancer pharmacotherapy is one of the most difficult obstacles to improve cancer therapy. The present research investigated cellular mechanisms of pharmacological action of chemotherapeutic agents and resistant mechanisms of cancer against the drug action. The methods we used were the latest proteomic and metabolomic analyses which measured intracellular expression of abundant proteins and metabolites. Based on comprehensive metabolomic fingerprints and protein expression analysis, we have discovered several new proteins and metabolites that are related to the chemo-sensitivity or drug resistance of cancer. These findings are expected to lead to develop a new personalized cancer pharmacotherapy.