ROLES OF EPIGENETIC MECHANISM IN HOMEOSTATIC CELL-CYCLE CONTROL IN NEURONAL STEM CELLS

表观遗传机制被认为是控制哺乳动物大脑皮层形成的神经元祖细胞（npc）细胞周期动力学的一种假定机制。根据我们之前的特异性基因过表达/功能丧失实验和子宫内暴露于二恶英分析的结果，我们观察到通过调节细胞周期每个阶段的长度来维持npc正常细胞周期长度的缓冲现象。综上所述，我们研究了表观遗传机制在体内形成大脑皮层的npc细胞周期调节中的作用。其中，组蛋白去乙酰化酶对组蛋白乙酰化的调控是研究的重点。

Epigenetic mechanisms are considered to be a putative machinery for controlling cell cycle kinetics of neuronal progenitor cells (NPCs) that forms cerebral cortex in mammals. According to our previous results from specific gene overexpression/loss-of-function experiments and in utero exposure to dioxin analysis, we have observed buffering phenomena to maintain normal cell cycle length of the NPCs by adjusting lengths of each phase of the cell cycle. Taken together, we investigated roles of epigenetic mechanisms in cell cycle regulation in NPCs which forms cerebral cortex in vivo. Especially, the research focus was put upon the regulation of histone acetylation by histone deacetylase.