Can modulation of oxidative stress in the brain be a breakthrough treatment for lower urinary tract symptoms?

大脑氧化应激的调节能否成为下尿路症状的突破性治疗方法？

• 批准号: 23390380
• 负责人: YOKOYAMA OSAMU
• 金额: $ 11.98万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390380/
• 关键词: メタボリック症候群; 下部尿路症状; 酸化ストレス; 膀胱虚血; 膀胱機能; 高血圧; 肥満; レニンアンギオテンシン; 食塩過剰; プロスタグランジン

We investigated,in rat models of metabolic syndrome (MetS) or salt-loading hypertension (HT),effects of MetS or HT on bladder function,associated changes in blood flow and epithelial mediators. These models showed frequent micturition. Amounts of ATP,PGE2 and NGF released from the stretched bladder epithelium were significantly increased. A significant decrease in blood flow was concomitant with increased oxidative stress. Angiotensin-II receptor blocker (ARB) and alpha1A blocker increased blood flow and decreased oxidative stress in the MetS bladder,resulting in suppression of detrusor overactivity. Score of lower urinary symptoms was found to be lower in male HT patients treated with ARB.Bladder ischemia and concomitant oxidative stress play an important role in development of storage dysfunction in MetS and HT via increases in release of ATP,PGE2 and NGF from the bladder epithelium. Agents increasing blood supply may improve micturition reflex via suppression of oxidative stress.

我们在代谢综合征（MetS）或盐负荷高血压（HT）大鼠模型中研究了MetS或HT对膀胱功能、血流量和上皮介质相关变化的影响。这些模型表现出频繁的排尿。膀胱上皮细胞释放的ATP、PGE2和NGF的量显著增加。血流量的显著减少伴随着氧化应激的增加。血管紧张素II受体阻滞剂（ARB）和α 1A阻滞剂增加血流量，降低MetS膀胱的氧化应激，从而抑制逼尿肌过度活动。ARB治疗的男性HT患者的下尿路症状评分较低。膀胱缺血和伴随的氧化应激通过增加膀胱上皮细胞释放ATP、PGE2和NGF，在MetS和HT储存功能障碍的发展中发挥重要作用。增加血液供应的药物可通过抑制氧化应激来改善排尿反射。

项目成果

Male LUTS: pleoropic pathogeneses -from a novel basic and clinical research

男性 LUTS：多效发病机制 - 来自一项新颖的基础和临床研究

• 发表时间: 2012
• 作者: Yokoyama;O.
• 通讯作者: O.

Efficacy of Fesoterodine on Nocturia and Quality of Sleep in Asian Patients With Overactive Bladder

• DOI: 10.1016/j.urology.2013.12.008
• 发表时间: 2014-04-01
• 期刊: UROLOGY
• 影响因子: 2.1
• 作者: Yokoyama, Osamu;Hiro, Shintaro;Yamagami, Hidetomi
• 通讯作者: Yamagami, Hidetomi

福井大学医学部研究活動一覧

福井大学医学部研究活动一览

The influences of 5alpha-reductase inhibitor dutasteride on contraction and alpha1-adrenoceptor expression in rat prostate

5α还原酶抑制剂度他雄胺对大鼠前列腺收缩及α1肾上腺素受体表达的影响

• 发表时间: 2012
• 期刊: Neurourology and Urodynamics
• 影响因子: 2
• 作者: Dong Wang;X. Zha;Keiko Nagase;Y. Hasegawa;I. Muramatsu;O. Yokoyama
• 通讯作者: O. Yokoyama

Imidafenacin, an antimuscarinic agent, improves nocturia and reduces nocturnal urine volume.

• DOI: 10.1016/j.urology.2013.05.017
• 发表时间: 2013-09
• 期刊: Urology
• 影响因子: 2.1
• 作者: O. Yokoyama;Y. Homma;O. Yamaguchi