Development of degradation controlled alloy with long-term release of bioactive metallic ion

通过动物植入实验，探讨了镁合金的生物降解机制及对新骨形成的影响。在皮下植入模型中，两种不同成分的镁合金表现出不同的降解速率。缓慢降解的镁合金显示出周围组织的快速组织。在骨内种植体模型中，镁合金表现出与皮下种植体相似的降解行为。新骨在镁合金周围形成。新骨形成逐渐增加，镁合金降解率高。在缓慢降解的镁合金中，骨表现为先增后减。镁合金与骨的接触率较高。镁合金与骨组织具有良好的相容性。

Biodegradaion mechanism and effect of new bone formation of magnesium alloys were examined by animal implant experiments. In subcutaneous implant model, Two magnesium alloys of different composition showed different degradation rate. Magnesium alloy of slow rate degradation revealed rapid organization of surrounded tissue. In intraosseous implant model, magnesium alloys showed similar degradation behavior to subcutaneous implant model. New bone was formed around magnesium alloys. New bone formation showed gradual increase in magnesium alloy with high rate degradation. In magnesium alloy with slow rate degradation, bone showed initial increase and afterwords gradual decrease. Magnesium alloys showed high contact rate with bone. Magnesium alloy were demonstrated the high compatibility to bone tissue.