Development of therapy targeting lipid mediator-related GPCRs for prevention of bone resorptive diseases
Development of therapy targeting lipid mediator-related GPCRs for prevention of bone resorptive diseases
批准号:
23390467
负责人:
HIKIJI Hisako
金额:
$12.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011-04-01 至 2014-03-31
中文摘要
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英文摘要
Lipids which mediate cell signals are called lipid mediators. Many lipid mediators exert their effects through G-protein coupled receptors (GPCR). We have investigated the lipid mediator-related GPCRs which prevent bone resorptive diseases. We have reported that gene ablation of the receptor of TDAG8 accerates the bone resorption. TDAG8, which has been considered as the GPCR of the lipids, is activated through the different mechanisms.
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DOI:
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发表时间:
2011
期刊:
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影响因子:
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发表时间:
2011
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DOI:
10.1002/j.0022-0337.2011.75.4.tb05081.x
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2011
期刊:
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共 37 条
Development of the new risk assessment using FMEA in the oral health care of the patient with oral lesion
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批准号:24659992
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2012
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负责人:HIKIJI Hisako
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依托单位:
Development of therapy targeting orphan GPCR-related lipid mediators for prevention of bone destruction
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批准号:20390508
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负责人:HIKIJI Hisako
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批准号:15592099
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targeting of iNOS with antisense DNA plasmid prevents cytokine-induced inhibition of osteoblastic differentiation
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批准号:13672082
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资助金额:$2.24万
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财政年份:2001
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负责人:HIKIJI Hisako
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依托单位:
Experimental study of transport distraction osteogenesis.-Molecular basis of bone metabolism-
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批准号:11671977
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财政年份:1999
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负责人:HIKIJI Hisako
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依托单位:
海外基金