Epidemiological study to clarify the mechanism of radiation induced thyroid cancer around Chernobyl

流行病学研究阐明切尔诺贝利周围辐射诱发甲状腺癌的机制

• 批准号: 23406020
• 负责人: TAKAMURA Noboru
• 金额: $ 12.15万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23406020/
• 关键词: 甲状腺がん; 放射線; 内部被ばく; チェルノブイリ; 甲状腺; 甲状腺結節

After the accident at the Chernobyl Nuclear Power Plant (CNPP), the incidence of thyroid cancer increased among children. To assess the prognosis of benign thyroid nodules in individuals living around the CNPP, we conducted a follow-up investigation of screening data from 1991 to 2000 in the Ukraine. Participants of this study were 160 inhabitants with thyroid nodules (nodule group) and 160 inhabitants without thyroid nodules (normal control group) intially identified by ultrasonography from 1991 to 2000.No thyroid nodules were observed among the normal control group participants. The prevalence of thyroid abnormality, especially nodules that could be cancerous (malignant or suspicious by fine needle aspiration biopsy), was 7.5% in the nodule group and 0% in the normal control group (P<0.001). Our study indicated that a thyroid nodule in childhood is a prognostic factor around Chernobyl.

切尔诺贝利核电站事故发生后，儿童甲状腺癌发病率上升。为了评估居住在CNPP周围的个体的良性甲状腺结节的预后，我们对乌克兰1991年至2000年的筛查数据进行了随访调查。本研究选取1991 ~ 2000年经超声检查确诊为甲状腺结节的160例（结节组）和160例未发现甲状腺结节的居民（正常对照组）为研究对象。结节组甲状腺异常率为7.5%，而正常对照组为0%（P<0.001），尤其是细针穿刺活检可疑癌性结节。我们的研究表明，儿童甲状腺结节是切尔诺贝利周围的预后因素。

项目成果

Prognosis of thyroid nodules in individuals living in the Zhitomir region of Ukraine.

• DOI: 10.1371/journal.pone.0050648
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Hayashida N;Sekitani Y;Takahashi J;Kozlovsky AA;Gutevych OK;Saiko AS;Nirova NV;Petrova AA;Rafalskiy RM;Chorny SA;Daniliuk VV;Anami M;Yamashita S;Takamura N
• 通讯作者: Takamura N

Evaluation of environmental contamination and estimated radiation dose for the return to residents’ homes in Kawauchi Village, Fukushima Prefecture.

福岛县川内村居民返回家中的环境污染和估计辐射剂量评估。

• 发表时间: 2013
• 期刊: PLoS ONE
• 影响因子: 3.7
• 作者: Taira Y;Hayashida N;Yamaguchi H;Endo Y;Yamashita S;Takamura N.
• 通讯作者: Takamura N.

Testosterone is an independent determinant of bone mineral density in men with type 2 diabetes mellitus

睾酮是 2 型糖尿病男性骨矿物质密度的独立决定因素

• 发表时间: 2011
• 期刊: Clin Chem Lab Med
• 影响因子: 6.8
• 作者: Vasilkova O;Mikhort T;Sanec I;Sharshakova T;Hayashida N;Takamura N
• 通讯作者: Takamura N

Assessment of Internal Exposure Doses in Fukushima by a Whole Body Counter Within One Month after the Nuclear Power Plant Accident

• DOI: 10.1667/rr3232.1
• 发表时间: 2013-06-01
• 期刊: RADIATION RESEARCH
• 影响因子: 3.4
• 作者: Matsuda, Naoki;Kumagai, Atsushi;Yamashita, Shunichi
• 通讯作者: Yamashita, Shunichi

Lessons from Chernobyl

切尔诺贝利的教训

• 发表时间: 2011
• 期刊: Fukushima J Med Sci
• 影响因子: 0.8
• 作者: Takamura N;Yamashita S
• 通讯作者: Yamashita S