Development of low invasive cerebral infarction model on Common Marmoset for cell therapy and regenerative medicine.

以往文献报道在不开颅的情况下建立了绒猴低创性脑梗死模型。该模型可通过可重复性方法建立。模型与人一样患有运动性偏瘫。神经功能缺损可通过神经评分和高速摄像机进行评估。神经放射学评估也可以通过MRI和PET进行。那么这个模型被认为是接近人类脑梗死的。组织学研究还分析了我们的模型梗死灶周围的再生。然而，观察到少许神经再生。为建立期待神经再生的脑梗死细胞治疗方法，采用立体定向手术将干细胞移植至模型基底神经节。本组模型术中、术后均无并发症发生。现对细胞移植模型进行分析。我们的模型被认为对脑梗死的研究非常有用。

Low invasive cerebral infarction model has been established on Common Marmoset without craniotomy reported in the past. The model can be made by reproducible method. The model suffers from motor hemiparesis as human. The neurological deficit can be evaluated by using neurological scorings and high speed camera. Neuroradiological assessment is also possible by using MRI and PET. Then this model is considered to be closed to human brain infarction. Histological study was also performed to analize regeneration around infarctional lesion in our model. However, neural regeneration was observed slightly. To establish cell therapy for brain infarction expecting neural regeneratoin, stem cell transplantation was performed into the basal ganglia in the model by stereotactic operation. In this operation, no complicaion was seen intra and after operation on the model. The cell transplantation model is analyzed now. Our model is considered to be extremely useful for study cerebral infarction.