Biological functional analysis of novel axon guidance molecule LOTUS

新型轴突导向分子LOTUS的生物学功能分析

• 批准号: 23500452
• 负责人: TAKEI Kohtaro
• 金额: $ 3.08万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500452/
• 关键词: 神経回路形成; 神経発生; 軸索伸長; 神経再生

In developing lateral olfactory tract (LOT) in mouse embryos, axonal branch was increased in LOTUS-deficient mice, whereas the axonal branch was decreased in NgR1-deficient mice. Furthermore, the axonal branch was also decreased in their double knocking-out mice, suggesting that Nogo-NgR1 interaction may induce axonal branching of LOT.On the other hand, doublecortin-positive migrating pyramidal neurons were found in inside area of dentate gylus of hippocampus in LOTUS-deficient mice when compared with the wild type mice, suggesting that LOTUS may be involved in neuronal migration in developing hippocampus

在缺乏荷花小鼠中，在小鼠胚胎中开发侧向嗅球（LOT）时，轴突分支增加，而NGR1缺陷小鼠的轴突分支减少。 Furthermore, the axonal branch was also decreased in their double knocking-out mice, suggesting that Nogo-NgR1 interaction may induce axonal branching of LOT.On the other hand, doublecortin-positive migrating pyramidal neurons were found in inside area of​​ dentate gylus of hippocampus in LOTUS-deficient mice when compared with the wild type mice, suggesting that LOTUS may be involved in neuronal发展海马的迁移

项目成果

内在性 Nogo 受容体アンタゴニスト LOTUS による神経突起伸長制御

内源性 Nogo 受体拮抗剂 LOTUS 控制神经突生长

• 发表时间: 2012
• 作者: 高橋慶太;栗原裕司;五嶋良郎;鈴木ゆめ;田中章景;竹居光太郎;小林勇喜 濱本明恵 高橋明義 斎藤祐見子;仲嶺三代美;竹居光太郎
• 通讯作者: 竹居光太郎

Nogo受容体に対するLOTUSの拮抗作用

LOTUS 对 Nogo 受体的拮抗作用

• 发表时间: 2012
• 作者: 栗原裕司、池谷真澄、伊藤拓夢、西山邦幸;榊原裕介、五嶋良郎、竹居光太郎
• 通讯作者: 榊原裕介、五嶋良郎、竹居光太郎

The carboxyl-terminal region of Crtac1B/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-1

• DOI: 10.1016/j.bbrc.2012.01.033
• 发表时间: 2012-02-10
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Kurihara, Yuji;Arie, Yuko;Takei, Kohtaro
• 通讯作者: Takei, Kohtaro

内在性Nogo受容体アンタゴニストの機能解析

内源性Nogo受体拮抗剂的功能分析

• 发表时间: 2012
• 作者: 栗原裕司;竹居光太郎
• 通讯作者: 竹居光太郎

Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones

生长锥中蛋白质翻译因子 eEF2 局部磷酸化介导的神经突生长调节

• DOI: 10.1002/dneu.22058
• 发表时间: 2013
• 期刊: Dev. Neurosci
• 作者: Iketani M.;Iizuka A.;Sengoku K.;Kurihara Y.;Nakamura F.;Sasaki Y.;Sato Y.;Yamane M.;Matsushita M.;Nairn A.C.;Takamatsu K.;Goshima Y.;Takei K.
• 通讯作者: Takei K.