Modulation of the amygdala synaptic neurotransmission that controls fear memory extinction

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Fear memory is critical for survival, but uncontrollable augmentation of this implicit memory sometimes occurs in particular psychiatric and neurological disorders. The aim of the present study was to elucidate the mechanisms that control fear memory using mice.As a result, we have found followings. (1) Fear memory is influenced by the balance of dietary polyunsaturated fatty acids via endocannabinoid neurotransmission. (2) Neonatal stress hormone (corticosterone) exposure suppresses adolescent fear memory extinction.Identification of the biological system that plays a modulatory role in fear memory is fundamental to understanding the adjustment of this memory process. It is expected that elucidation of the control mechanisms aids in developing new treatment for disorders in which fear is a contributory factor.