Modulation of the amygdala synaptic neurotransmission that controls fear memory extinction

恐惧记忆对生存至关重要，但这种内隐记忆的不可控制的增强有时会发生在特殊的精神和神经疾病中。本研究的目的是阐明控制小鼠恐惧记忆的机制。结果，我们发现了以下几点。(1)饮食多不饱和脂肪酸平衡通过内源性大麻素神经传递影响恐惧记忆。(2)新生儿应激激素（皮质酮）暴露抑制青少年恐惧记忆消退。识别在恐惧记忆中起调节作用的生物系统是理解这一记忆过程调整的基础。预期控制机制的阐明有助于开发新的治疗方法，其中恐惧是一个促成因素。

Fear memory is critical for survival, but uncontrollable augmentation of this implicit memory sometimes occurs in particular psychiatric and neurological disorders. The aim of the present study was to elucidate the mechanisms that control fear memory using mice.As a result, we have found followings. (1) Fear memory is influenced by the balance of dietary polyunsaturated fatty acids via endocannabinoid neurotransmission. (2) Neonatal stress hormone (corticosterone) exposure suppresses adolescent fear memory extinction.Identification of the biological system that plays a modulatory role in fear memory is fundamental to understanding the adjustment of this memory process. It is expected that elucidation of the control mechanisms aids in developing new treatment for disorders in which fear is a contributory factor.