Polarization analysis of age-related changes of the crystalline lens with high sensitivity OCT

高灵敏度OCT对晶状体年龄相关变化的偏振分析

• 批准号: 23500529
• 负责人: FURUKAWA Hiroyuki
• 金额: $ 3.33万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500529/
• 关键词: OCT; 医用生体工学; 光干渉断層計測; 偏光感受型OCT; 生体計測; 前眼部OCT; 生体医工学; 偏光計測; 偏光

We developed a high-speed, high-sensitivity, swept-source optical coherence tomography (SS-OCT) system with a depth range of 12 mm and a fast A-scan rate of 20,000 times per second, providing high-quality imaging of the whole anterior segment. Using this SS-OCT system, we measured curvature of the anterior and posterior surfaces of the lens, thickness of the lens, and anterior chamber depth in response to far (0.4 D) and near (10 D) accommodative stimulus targets. The radius of curvature of the anterior and posterior surface of the human lens became smaller with accommodation, and changes in the anterior surface were larger than the posterior. Morphometric changes of the lens with accommodation reduced with aging, except for posterior surface curvature.

我们开发了一种高速、高灵敏度、扫描源光学相干断层扫描(SS-OCT)系统，深度范围为12 mm，快速A扫描速度为每秒20,000次，提供高质量的整个前段图像。使用SS-OCT系统，我们测量了晶状体前后表面的曲率、晶状体厚度和前房深度对远(0.4D)和近(10D)调节刺激目标的反应。人晶状体前、后表面的曲率半径随调节时间的延长而减小，且前表面的变化大于后表面的变化。除后表面曲率外，晶状体的形态计量学变化随年龄的增长而减少。

项目成果

Imaging the Whole Anterior Segment of Human Accommodation by Swept-Source Optical Coherence Tomography

通过扫频光学相干断层扫描对人类调节的整个前段进行成像

• 发表时间: 2011
• 作者: Hiroyuki Furukawa;Hideaki Hiro-Oka;Nobuyuki Satoh;Reiko Yoshimura;Donghak Choi;Motoi Nakanishi;Akihito Igarashi;Kohji Ohbayashi;Kimiya Shimizu
• 通讯作者: Kimiya Shimizu

Discretely swept optical coherence tomography system using super-structure grating distributed Bragg reflector lasers at 1561-1639nm

使用1561-1639nm超结构光栅分布式布拉格反射激光器的离散扫描光学相干断层扫描系统

• DOI: 10.1117/12.905413
• 发表时间: 2012
• 期刊: Proc. SPIE, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
• 作者: Donghak Choi;Reiko Yoshimura; Hideaki Hiro-Oka; Hiroyuki Furukawa; Atsushi Goto;Nobuyuki Satoh;Akihito Igarashi;Motoi Nakanishi;Kimiya Shimizu;Kohji Ohbayashi
• 通讯作者: Kohji Ohbayashi

Image diversity , shape modification with accommodation , dynamical change with accommodation, and age dependence of the ciliary body imaged by optical coherence tomography

通过光学相干断层扫描成像的睫状体的图像多样性、调节的形状修改、调节的动态变化以及睫状体的年龄依赖性

• DOI: 10.1117/12.905401
• 发表时间: 2012
• 期刊: Proc. SPIE , Ophthalmic Technologies XXII
• 作者: Kimiya Shimizu;Nobuyuki Satoh;Akihito Igarashi;Motoi Nakanishi;Atsushi Goto;Donghak Choi;Reiko Yoshimura;Hideaki Hiro-Oka ;Hiroyuki Furukawa ;Kohji Ohbayashi
• 通讯作者: Kohji Ohbayashi

高深達度OCTを用いた全前眼部のイメージング

使用高深度穿透 OCT 对整个眼前节进行成像

• 作者: 田村典子;他;田村典子;岡島恵子，藤堂敦，佐久間俊，山口梢，水野（松本）由子;古川裕之，廣岡秀明，常廣俊太郎，大林康二，清水公也
• 通讯作者: 古川裕之，廣岡秀明，常廣俊太郎，大林康二，清水公也

Accommodative changes in human eye observed by Kitasato anterior segment optical coherence tomography

• DOI: 10.1007/s10384-012-0208-6
• 发表时间: 2013-04
• 期刊: Japanese Journal of Ophthalmology
• 影响因子: 2.4
• 作者: N. Satoh;K. Shimizu;A. Goto;A. Igarashi;K. Kamiya;K. Ohbayashi