Polarization analysis of age-related changes of the crystalline lens with high sensitivity OCT

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We developed a high-speed, high-sensitivity, swept-source optical coherence tomography (SS-OCT) system with a depth range of 12 mm and a fast A-scan rate of 20,000 times per second, providing high-quality imaging of the whole anterior segment. Using this SS-OCT system, we measured curvature of the anterior and posterior surfaces of the lens, thickness of the lens, and anterior chamber depth in response to far (0.4 D) and near (10 D) accommodative stimulus targets. The radius of curvature of the anterior and posterior surface of the human lens became smaller with accommodation, and changes in the anterior surface were larger than the posterior. Morphometric changes of the lens with accommodation reduced with aging, except for posterior surface curvature.