A novel intervention of phase II cardiac rehabilitation for patients with multiple complications to advance their social reintegration

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Increased insulin resistance is closely correlated with exercise capacity in patients with hypertension (HT) and/or dyslipidemia (DL), because it is known to impair the energy metabolism in skeletal muscles. The aim of this study was to investigate the influence of insulin resistance on exercise capacity in patients with HT and/or DL.Homeostasis model assessment ratio (HOMA-R) was assessed and oxygen uptake (VO2) at anaerobic threshold (VO2 AT) and peak VO2 were measured by cardiopulmonary exercise testing. The exercise capacity was assessed using ratios of measured VO2 to predicted VO2 AT and predicted peak VO2 (%VO2 AT and %peak VO2, respectively).The %VO2 AT and %peak VO2 were significantly lower in the high HOMA-R group than in the low HOMA-R group (P<0.05, respectively), and negatively correlated with HOMA-R (r=0.339, P<0.05 and r=0.522, P<0.05, respectively). The present study showed that increased insulin resistance decreased exercise capacity in patients with HT and/or DL.