Effects of daily physical activity with bone mass in hemodialysis patients

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Purpose: This study aimed to determine whether daily physical activity is associated with bone mass in hemodialysis (HD) patients. Methods: In cross-sectional Study 1, 150 HD outpatients undergoing maintenance HD 3 times a week were recruited. Clinical characteristics and biochemical parameters were measured. Bone mass was assessed by quantitative ultrasound measurement at the calcaneus. Physical activity (steps) was measured using an accelerometer. In 2-year follow-up Study 2, participants were divided into two subgroups according to physical activity based on results from Study 1 (more than 5,000 steps per day or not). Results: Adjusted multiple regression analysis in Study 1 indicated that physical activity was significantly associated with bone mass for each sex. ANOVA showed that changes in bone mass were significantly different between the two subgroups for each sex in Study 2. Conclusion: Decreased daily physical activity is strongly associated with bone loss in HD patients.