The molecular biology and biochemistry of bacterial manganese oxidation

细菌锰氧化的分子生物学和生物化学

• 批准号: DP0342541
• 负责人: Prof Lindsay Sly
• 金额: $ 15.97万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0342541
• 关键词: molecular; biology; biochemistry; bacterial; manganese

This project will further the understanding of bacterial manganese (Mn2+) oxidation. A multi-disciplinary approach will be used to further investigate the genetics and biochemistry of the Mn2+-oxidising systems of Pseudomonas putida, Leptothrix sp. and Pedomicrobium sp. This work will focus in particular on comparing the Mn2+-oxidising systems from unrelated bacteria. A combination of molecular biology, protein biochemistry and spectroscopy will be used. This will be the first time that the enzymes of bacterial Mn2+-oxidation will have been characterised in such detail and will lead to a greater understanding of the process of bacterial manganese oxidation.

该项目将进一步加深对细菌氧化锰（Mn2+）的认识。一个多学科的方法将被用于进一步研究恶臭假单胞菌、细螺旋体和土壤微生物的Mn2+氧化系统的遗传学和生物化学。这项工作将特别侧重于比较来自不相关细菌的Mn2+氧化系统。结合分子生物学、蛋白质生物化学和光谱学。这将是第一次对细菌氧化Mn2+的酶进行如此详细的表征，并将使人们对细菌氧化锰的过程有更深入的了解。