Division of Chemical Toxicology Symposia at the 266th National ACS Meeting

项目摘要/摘要 此应用程序的目标是获得美国化学学会化学分会的支持 毒理学(Toxi)第266届全国会议计划，将于2023年8月13日至17日在 加利福尼亚州旧金山化学毒理学分部的使命是改善人类健康和 通过促进对控制疾病过程的化学机制的了解和 药物、环境制剂和内源性化学物质的毒性。我们的目标包括提供 交流化学毒理学领域的研究，鼓励化学研究的论坛 毒性的机制，以及促进学术、工业和政策之间的联系 共同感兴趣的领域。我们也致力于发展领导力和专业发展。 各级科学家的技能。因此，请拨的资金将用于支持旅行奖励和 研究生、博士后学者和初级教职员工的费用。整体的毒物计划是 围绕“影响人类健康的毒物学预测、标记物和结果”的主题组织 并补充了全国会议的主题--利用数据的力量。该计划包括 五个专题研讨会，其中将邀请不同的知名和 新兴的调查人员，对每个主题都有不同的观点。五个专题研讨会分别是：(一) 《增广人工智能在毒物代谢预测中的应用》，与 化学信息部(CINF)和药物化学部(MEDI)，将探索 增强人工智能预测有毒代谢物；(2)“毒性和抑制导致的药物-药物相互作用” 与MEDI共同推动的“转运蛋白”将研究抑制转运蛋白调控药物的影响 (3)与MEDI共同推动的“化学毒性的高级体外模型”，重点是最近的 芯片上器官系统在检测化学毒性方面的进展；(4)“将毒理学和 通过暴露体促进人类健康“，与生物化学(Biol)和科室共同促进 环境化学(ENVR)，描述了测量化学暴露寿命的最新进展 以及(5)“衰老和疾病中的内源性代谢物”， 与Biol共同推动，专注于细胞反应不足的化学和生物学 内源性代谢物形成失调。科学计划显然与 NIEHS的使命。

Project Summary/Abstract The goal of this application is to obtain support for the American Chemical Society Division of Chemical Toxicology (TOXI) at the 266th 2023 National Meeting program, which will be held August 13-17, 2023, in San Francisco, CA. The mission of the Division of Chemical Toxicology is to improve human health and public welfare by promoting the understanding of chemical mechanisms that govern disease processes and the toxicity of drugs, environmental agents, and endogenous chemicals. Our goals include providing a forum for communicating research in the field of chemical toxicology, encouraging research in chemical mechanisms of toxicity, and facilitating connections between academia, industry, and policy in scientific areas of mutual interest. We are also committed to developing the leadership and professional development skills of scientists at all levels. Thus, the requested funds will be used to support travel awards and expenses for graduate students, postdoctoral scholars, and junior faculty. The overall TOXI program is organized around the theme of “Toxicological Predictions, Markers, and Outcomes Affecting Human Health” and complements the National Meeting theme of Harnessing the Power of Data. The program includes five thematic symposia, which will feature invited oral presentations by a diverse group of established and emerging investigators with a range of perspectives on each topic. The five thematic symposia are: (1) “Application of Augmented Artificial Intelligence in Toxicology Metabolism Prediction”, co-promoted by the Divisions of Chemical Information (CINF) and Medicinal Chemistry (MEDI), will explore the role of augmented AI in predicting toxic metabolites; (2) “Toxicity & Drug-Drug Interactions Resulting from Inhibition of Transporters”, co-promoted with MEDI, will examine the impact of inhibiting transporters to regulate drug efficacies; (3) “Advanced in vitro Models for Chemical Toxicity,” co-promoted with MEDI, focuses on recent progress in development of organ-on-chip systems on testing chemical toxicity; (4) “Linking Toxicology and Human Health Through the Exposome”, copromoted with the Divisions of Biological Chemistry (BIOL) and Environmental Chemistry (ENVR), describes recent advances in measuring lifetime of chemical exposures and disparities in vulnerable populations; and (5) “Endogenous Metabolites in Aging and Disease”, copromoted with BIOL, focuses on the chemistry and biology that underly cellular responses to misregulated formation of endogenous metabolites. The scientific program is clearly aligned with the mission of NIEHS.