Effects of obesity-related genes and lifestyle on the accumulation of visceral fat area

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Obesity is both environmentally and genetically influenced. Candidate obesity-related genes include those that enclose B3AR, B2AR and UCP1. However, there are no reports on the effects of obesity-related genes on visceral fat area (VFA). We examined the involvement of genetic factors and environmental factors in the accumulation of VFA. The subjects were 267 Japanese (81 men and 186 women) aged 20-72 years old. VFA values by CT imaging, blood samples and questionnaires were obtained from all subjects.A comparison of the mean of VFA according to the polymorphism in three kinds of genes, did not reveal a significant difference among the polymorphism. In addition, we adjusted the data for age, exercise habit and walking time, and analyzed the mean of VFA, but did not find a significant difference. However, a significant difference in VFA was found with differences in exercise habit. It is suggested that increased exercise leads to a decrease of VFA.