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Effects of obesity-related genes and lifestyle on the accumulation of visceral fat area

肥胖相关基因及生活方式对内脏脂肪面积堆积的影响

基本信息

批准号：
23500837
负责人：
KOMIYA HIDEAKI
金额：
$ 3.16万
依托单位：
Utsunomiya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2013
项目状态：
已结题

项目摘要

Obesity is both environmentally and genetically influenced. Candidate obesity-related genes include those that enclose B3AR, B2AR and UCP1. However, there are no reports on the effects of obesity-related genes on visceral fat area (VFA). We examined the involvement of genetic factors and environmental factors in the accumulation of VFA. The subjects were 267 Japanese (81 men and 186 women) aged 20-72 years old. VFA values by CT imaging, blood samples and questionnaires were obtained from all subjects.A comparison of the mean of VFA according to the polymorphism in three kinds of genes, did not reveal a significant difference among the polymorphism. In addition, we adjusted the data for age, exercise habit and walking time, and analyzed the mean of VFA, but did not find a significant difference. However, a significant difference in VFA was found with differences in exercise habit. It is suggested that increased exercise leads to a decrease of VFA.

肥胖既受环境因素的影响，也受遗传因素的影响。候选肥胖相关基因包括包围B3AR、B2AR和UCP1的基因。然而，目前还没有关于肥胖相关基因对内脏脂肪面积(VFA)影响的报道。我们研究了遗传因素和环境因素在VFA积累中的作用。研究对象为267名日本人(男81人，女186人)，年龄20-72岁。所有受试者均通过CT扫描、血样和问卷调查获得VFA值，根据三种基因的多态性将VFA的平均值进行比较，未发现三种基因的多态性之间存在显著差异。此外，我们调整了年龄、运动习惯和步行时间的数据，并对VFA的平均值进行了分析，但没有发现显著差异。但运动习惯不同，VFA差异显著。提示增加运动量会导致VFA的降低。