Effects of plant polyphenols intake during lactation on glucose and lipid metabolism in offspring exposed with maternal protein restriction

哺乳期植物多酚摄入对母体蛋白质限制后代糖脂代谢的影响

• 批准号: 23500960
• 负责人: SATO SHIN
• 金额: $ 3.33万
• 依托单位: Aomori University of Health and Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500960/
• 关键词: 胎生期低栄養; 肥満; 糖尿病; AMP活性化プロテインキナーゼ; エネルギー代謝; 植物ポリフェノール; エピジェネティクス; 胎児期低栄養; AMPK活性化プロテインキナーゼ; ポリフェノール

Dietary protein restriction during pregnancy is thought to lead to the development of obesity and glucose intolerance in later life. This study was investigated the effects of maternal plant polyphenols intake during lactation affects AMP-activated protein kinase (AMPK) phosphorylation in the liver of young and adult offspring exposed to fetal malnutrition. Maternal plant polyphenols (azuki bean polyphenols and resveratrol) intake during lactation increased AMPK phosphorylation in the liver of offspring. The results suggest that plant polyphenols intake during lactation activate hepatic AMPK and may affect the glucose and lipid metabolism in adult offspring exposed with maternal protein restriction.

怀孕期间的饮食蛋白质限制被认为会导致以后生活中肥胖和葡萄糖耐受不良的发展。本研究探讨了哺乳期母体植物多酚摄入量对胎儿营养不良的幼仔和成年仔肝脏AMP活化蛋白激酶（AMPK）磷酸化的影响。母体植物多酚（红豆多酚和白藜芦醇）在哺乳期摄入增加AMPK磷酸化的后代的肝脏。结果表明，植物多酚摄入在哺乳期激活肝脏AMPK，并可能影响成年后代暴露于母体蛋白质限制的葡萄糖和脂质代谢。

项目成果

Effect of lignin-derived lignophenols on vascular oxidative stress and inflammation in streptozotocin-induced diabetic rats

木质素衍生的木质酚对链脲佐菌素诱导的糖尿病大鼠血管氧化应激和炎症的影响

• DOI: 10.1007/s11010-010-0645-9
• 发表时间: 2011
• 期刊: Molecular and Cellular Biochemistry
• 影响因子: 4.3
• 作者: Mukai Y;Norikura T;Fujita S;Mikame K;Funaoka M;Sato S
• 通讯作者: Sato S

Fructose intake during pregnancy up-regulates the expression of maternal and fetal hepatic sterol regulatory element-binding protein-1c in rats

• DOI: 10.1007/s12020-012-9815-8
• 发表时间: 2013-08-01
• 期刊: ENDOCRINE
• 影响因子: 3.7
• 作者: Mukai, Yuuka;Kumazawa, Maya;Sato, Shin
• 通讯作者: Sato, Shin

妊娠期のフルクトース摂取が胎児肝臓の脂質代謝関連遺伝子発現に及ぼす影響

孕期果糖摄入对胎儿肝脏脂质代谢相关基因表达的影响

• 发表时间: 2012
• 作者: 向井友花;熊澤麻耶;佐藤 伸
• 通讯作者: 佐藤 伸

Functional and Medical Foods with Bioactive Compounds: Science and Practical Application

含有生物活性化合物的功能性和医用食品：科学与实际应用

• 发表时间: 2013
• 作者: Sato S;Mukai Y;Kurasaki M
• 通讯作者: Kurasaki M

Effect of lignin-derived lignophenols on hepatic lipid metabolism in rats fed a high-fat diet.

木质素衍生的木质酚对高脂饮食大鼠肝脏脂质代谢的影响。

• DOI: 10.1016/j.etap.2012.04.005
• 发表时间: 2012
• 期刊: Environmental Toxicology and Pharmacology
• 影响因子: 4.3
• 作者: Sato S;Mukai Y;Tokuoka Y;Mikame K;Funaoka M;Fujita S.
• 通讯作者: Fujita S.