Effects of plant polyphenols intake during lactation on glucose and lipid metabolism in offspring exposed with maternal protein restriction

怀孕期间的饮食蛋白质限制被认为会导致以后生活中肥胖和葡萄糖耐受不良的发展。本研究探讨了哺乳期母体植物多酚摄入量对胎儿营养不良的幼仔和成年仔肝脏AMP活化蛋白激酶（AMPK）磷酸化的影响。母体植物多酚（红豆多酚和白藜芦醇）在哺乳期摄入增加AMPK磷酸化的后代的肝脏。结果表明，植物多酚摄入在哺乳期激活肝脏AMPK，并可能影响成年后代暴露于母体蛋白质限制的葡萄糖和脂质代谢。

Dietary protein restriction during pregnancy is thought to lead to the development of obesity and glucose intolerance in later life. This study was investigated the effects of maternal plant polyphenols intake during lactation affects AMP-activated protein kinase (AMPK) phosphorylation in the liver of young and adult offspring exposed to fetal malnutrition. Maternal plant polyphenols (azuki bean polyphenols and resveratrol) intake during lactation increased AMPK phosphorylation in the liver of offspring. The results suggest that plant polyphenols intake during lactation activate hepatic AMPK and may affect the glucose and lipid metabolism in adult offspring exposed with maternal protein restriction.