Importance of intestinal bacteria and dietary habits to maintain human health

我们寻找能够诱导产生白细胞介素-10细胞的肠道细菌。无菌条件下小鼠小肠黏膜B细胞样细胞数量很少，但随着年龄的增长或SPF小鼠粪便的增加而增加。革兰氏阳性细菌的抗生素减少了这种细胞群，而在革兰氏阳性细菌肠球菌单相关小鼠中增加了这种细胞群。这个群体还产生了白细胞介素22，它可以介导抗菌肽的产生和组织修复。该群体的部分纯化部分对幼稚T细胞转移小鼠的结肠炎有抑制作用，并通过注射抗白细胞介素-10抗体来消除这种作用。

We searched intestinal bacteria which can induce interleukin-10-producing cells. B cell-like cell population in mucosa of mouse small intestine was very little under germ free condition, but increased age-dependently or by administration of SPF mice feces. This cell population was decreased by antibiotics for Gram-positive bacteria, and increased in mice monoassociated with Enterococcus, an Gram-positive bacteria. This population additionally produced interleukin-22 which can mediate the production of antibacterial peptide and tissue repair. Partially purified fraction of this population showed inhibitory effect on colitis in naive T cell-transferred mice, and the effect was cancelled by injection of anti-interleukin-10 antibody.