Importance of intestinal bacteria and dietary habits to maintain human health

我们寻找了能够诱导白细胞介素-10产生细胞的肠道细菌。 在无菌条件下，小鼠小肠粘膜中的B细胞样细胞数量很少，但随年龄增长或SPF小鼠粪便给药而增加。 这种细胞群减少抗生素的革兰氏阳性菌，并增加与肠球菌，革兰氏阳性菌单相关的小鼠。 该群体还产生白细胞介素-22，其可以介导抗菌肽的产生和组织修复。该群体的部分纯化的级分显示出对幼稚T细胞转移小鼠中的结肠炎的抑制作用，并且该作用通过注射抗白细胞介素-10抗体而被取消。

We searched intestinal bacteria which can induce interleukin-10-producing cells. B cell-like cell population in mucosa of mouse small intestine was very little under germ free condition, but increased age-dependently or by administration of SPF mice feces. This cell population was decreased by antibiotics for Gram-positive bacteria, and increased in mice monoassociated with Enterococcus, an Gram-positive bacteria. This population additionally produced interleukin-22 which can mediate the production of antibacterial peptide and tissue repair. Partially purified fraction of this population showed inhibitory effect on colitis in naive T cell-transferred mice, and the effect was cancelled by injection of anti-interleukin-10 antibody.