The onset-preventing and suppressive effects of antioxidants on non-alcoholic steatohepatitis in mice

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Non-alcoholic steatohepatitis (NASH) is considered to be one of the important lifestyle-related diseases that are not currently manageable medically. No definite clinical effects have as yet been recognized.We noted that this disease develops with oxidative stress and thus conducted an examination on NASH prevention focusing mainly on the development of disease models and administration of antioxidants. It was confirmed that the disease which stably develops over a relatively-short time period in STAM mice, a new disease model, is very similar to the human disease NASH. We also examined the effects of administering vitamin E, amino acids (isoleucine, leucine), and D-allose, an isomer of D-glucose, using these mice and found that the administration of these substances significantly prevented liver disorders in STAM mice.