Development of the theory and program for the survival time model with covariates subject to measurement error.

开发具有测量误差的协变量的生存时间模型的理论和程序。

• 批准号: 05680253
• 负责人: NAKAMURA Tsuyoshi
• 金额: $ 0.64万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05680253/
• 关键词: Measurement Error; Regression Model; Misclassification; Survival Time Analysis; Atomic Bomb Survivors; Framingham Hear Study Data; 比例ハザードモデル

The paper describing the theoretical aspects of the method for the proportional hazards measurement error model, or generally referred to as the Cox-regression model, has been published from the Environmental Health Perspectives and a FORTRAN program implementing the method from the Computer Methods and Programs in Biology and Medicine. We have also constructed a method for finding asymptotically unbiased estimates adjusting for the misclassification in discrete convariate models and reported the results at the Joint Conference for the International Society for the Envirobnmental Epidemiology and the Exposure Analysis (REsearch Triangle Park, North Carolina, 1994), which is under preparation for submitting for publication in certain European journal.Analysis of the effect of the radiation doses on the A-bomb survivors followed-up by the Radiation Effect Research Foundation is as important application of the results of this study project. Not very reliable method has been proposed by so … More me statisticians of RERF for the analysis adjusting for the uncertainty of the dose-estimation, which failed to obtain even variance estimation of the estimates. Considering the importance of the results of the analysis for social life and political decision, we have developed a theory to apply the method obtained from this research project to the A-bomb survivors data to find mor reliable estimates for the radiation dose effects on human mortality. The method basically assumes the Poisson regression model, like RERF,and proposes a simple correction to the likelihood, which yields asymptotically unbiased estimates with valid variance estimates. Since we have obtained the summary data from RERF,we will analyze it with the method after close investigation into the data structure.We have also obtained a magnetic tape including the Framingham Heart Study Follow-up Data from NIH to apply the developed method to find out the effect of cholesterol and/or blood pressure on the cardiovascular risk adjusting for the measurement error in those laboratory test results.Thus we have successfully finished the study project, published the main results from well circulated journals and are going to apply the results to some of the important cohort data. Less

描述比例风险测量误差模型（或通常称为Cox回归模型）方法的理论方面的论文已发表于《环境健康展望》和《生物学和医学计算机方法和程序》中实现该方法的FORTRAN程序。我们还构建了一种方法，用于寻找调整离散协变量模型中错误分类的渐近无偏估计，并在国际环境流行病学和暴露分析学会联合会议上报告了结果（研究三角公园，北卡罗来纳州，1994年），该报告现正准备在欧洲某刊物发表。以下是辐射剂量对原子弹爆炸幸存者的影响的分析：由辐射效应研究基金会作为本研究项目成果的重要应用。不太可靠的方法已经提出了这样的 ...更多信息 RERF的统计学家进行分析，调整剂量估计的不确定性，未能获得估计值的均匀方差估计。考虑到分析结果对社会生活和政治决策的重要性，我们发展了一种理论，将本研究项目获得的方法应用于原子弹幸存者数据，以找到莫尔可靠的估计辐射剂量对人类死亡率的影响。该方法基本上假设泊松回归模型，如RERF，并提出了一个简单的校正的可能性，从而产生渐近无偏估计与有效的方差估计。由于我们从RERF获得了汇总数据，我们将在仔细研究数据结构后用该方法进行分析，并从NIH获得了一卷包含心脏研究随访数据的磁带，以应用所开发的方法来找出胆固醇和/或或血压对心血管风险的影响，并对这些实验室检查结果中的测量误差进行调整。因此，我们成功地完成了该研究项目的主要结果发表在发行量很大的期刊上，并将把这些结果应用于一些重要的队列数据。少

项目成果

Hiroyuki Mori: "Early Mortality of Atomic Bomb Survivors Based on House Reconstruction Survey" International.J.Radiation Biology. 66. 267-275 (1994)

Hiroyuki Mori：“基于房屋重建调查的原子弹幸存者的早期死亡率”International.J.Radiation Biology。

Tsuyoshi Nakamura: "Carrected Likelihoud for Proportional Hazards Meaurement Error Model and its Application" Environmental Health Perspectives. 102. 21-24 (1944)

Tsuyoshi Nakamura：“比例危险测量误差模型的预测似然及其应用”环境健康视角。

Tsuyoshi Nakamura: "Adjusting for Exposure Misclassification in Risk Assessment" Proceedings of the Joint Conference of International Society of Environmental Epidemiology and Exposure Analysis, Research Triangle Parl, North Carolinna. 18-21 (1994)

Tsuyoshi Nakamura：“调整风险评估中的暴露错误分类”国际环境流行病学和暴露分析​​学会联合会议论文集，研究三角帕尔，北卡罗来纳州。

中村 剛: "統計的方法の10年と求められている新手法" 医療情報学. 13. 82-83 (1994)

Tsuyoshi Nakamura：“十年来的统计方法和新方法的需求”医学信息学 13. 82-83 (1994)。

Hiroyuki Mori, Tsuyoshi Nakamura, Mariko Mine and D.G.Hoel: "Early Mortality of Atomic Bomb Survivors Based on House Reconstruction Survey" International Journal of Radiation Biology. Vol.66. 267-275 (1994)

Hiroyuki Mori、Tsuyoshi Nakamura、Mariko Mine 和 D.G.Hoel：“基于房屋重建调查的原子弹幸存者的早期死亡率”国际辐射生物学杂志。