Role of leptin signal in inflammation-related colorectal carcinogenesis

瘦素信号在炎症相关结直肠癌发生中的作用

• 批准号: 23501262
• 负责人: KOHNO Hiroyuki
• 金额: $ 3.24万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23501262/
• 关键词: 炎症とがん; レプチン; 発がん; 大腸がん; 高脂血症; 大腸発がん

Leptin is elevated in obesity and may be involved in carcinogenesis including colorectal cancers. The objective of this study was to investigate the role of leptin signal on colitis-related colon carcinogenesis.In current study, we indicated that Leptin was effective in inhibiting colitis-related colon carcinogenesis through suppression of mucosal inflammation and hyperlipidemia in the ob/ob mice (leptin-deficient obese genetic background). Our results suggest that the leptin might be useful for prevention of inflammation-related colon cancers.Furthermore, we showed that C57BL/KsJ mice strains are less sensitive to inflammation-related colon carcinogenesis compared with C57BL/6J mice and these differences may be due to the difference in their levels of mucosal inflammation of the colon. These results provided the useful information in the inflammation-related mouse colon carcinogenesis model.

瘦素在肥胖症中升高，并可能参与包括结肠直肠癌在内的致癌作用。本研究的目的是探讨瘦素信号在结肠炎相关结肠癌发生中的作用，在本研究中，我们发现瘦素通过抑制肥胖基因背景的ob/ob小鼠（瘦素缺陷型肥胖小鼠）的粘膜炎症和高脂血症而有效抑制结肠炎相关结肠癌的发生。我们的研究结果表明，瘦素可能是有用的预防炎症相关的结肠癌。此外，我们发现，C57 BL/KsJ小鼠品系是较不敏感的炎症相关的结肠癌的发生与C57 BL/6 J小鼠相比，这些差异可能是由于不同的结肠粘膜炎症水平。这些结果为炎症相关小鼠结肠癌模型的建立提供了有用的信息。

项目成果

The effect of hedgehog singnaling pathway in colonic carcinogenesis

Hedgehog信号通路在结肠癌发生中的作用

• 发表时间: 2012
• 作者: Okuno;J.;A. Abe-Ouchi;F. Saito;K. Takahashi;尾山武
• 通讯作者: 尾山武

Effect of cyclopamine, a specific hedgehog pathway inhibitor, on colitis associated carcinogeneseis

环巴明（一种特定的刺猬通路抑制剂）对结肠炎相关致癌的作用

• 发表时间: 2011
• 作者: 尾山武;甲野裕之
• 通讯作者: 甲野裕之

Leptin suppresses inflammation-related large bowel carcinogenesis in male ob/ob mice

瘦素抑制雄性 ob/ob 小鼠炎症相关的大肠癌发生

• 发表时间: 2013
• 作者: H.Kohno;T.Oyama
• 通讯作者: T.Oyama

The Effect of the Hedgehog Signaling Pathway in Colonic Carcinogenesis

Hedgehog信号通路在结肠癌发生中的作用

• 发表时间: 2012
• 作者: T.Oyama;R.Nakamura;H.Kohno
• 通讯作者: H.Kohno