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Single-cell analysis of T-cell receptor repertoire of HTLV-1 Tax-specific cytotoxic T cells in patients with adult T-cell leukemia/lymphoma.

Single-cell analysis of T-cell receptor repertoire of HTLV-1 Tax-specific cytotoxic T cells in patients with adult T-cell leukemia/lymphoma.
对成人 T 细胞白血病/淋巴瘤患者 HTLV-1 Tax 特异性细胞毒性 T 细胞的 T 细胞受体库进行单细胞分析。
批准号:
23501286
负责人:
KANDA Yoshinobu
金额:
$3.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
We analyzed the T-cell receptor repertoire of HTLV-1 Tax-specific cytotoxic T cells in patients with adult T-cell leukemia/lymphoma. We found that the Tax-CTLs share P-D/P-R motif, persist as effector memory CTLs for long term after transplantation, and show universal killing activity against third-party HTLV-I infected cells. We are planning a redirected T-cell immunotherapy using T-cell receptor alpha/beta genes from these clones.
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会议论文
Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation.
脐带血干细胞移植后与供体来源的骨髓增生异常综合征相关的单克隆丙种球蛋白病的复发。
DOI: 10.1016/j.exphem.2011.09.002
发表时间: 2011
期刊: Experimental Hematology
影响因子: 2.6
作者: [Rie Yamazaki, Yoshinobu Kanda, et al.]
通讯作者: et al.
Long-term persistence of limited HTLV-I Tax-specific cytotoxic T cell clones in a patient with adult T cell leukemia/lymphoma after allogeneic stem cell transplantation.
成人 T 细胞白血病/淋巴瘤患者在同种异体干细胞移植后,有限的 HTLV-I Tax 特异性细胞毒性 T 细胞克隆长期持续存在。
DOI: 10.1007/s10875-012-9729-5
发表时间: 2012
期刊: J Clin Immunol
影响因子: 9.1
作者: [Tanaka Y, Nakasone H, Yamazaki R, Kanda Y, et al.]
通讯作者: et al.
Universal cytotoxic activity of a HTLV-1 Tax-specific T cell clone from an HLA-A*24 : 02+ patient with adult T-cell leukemia against a variety of HTLV-I-infected T-cells
来自患有成人 T 细胞白血病的 HLA-A*24 : 02 患者的 HTLV-1 Tax 特异性 T 细胞克隆针对多种 HTLV-I 感染的 T 细胞的通用细胞毒活性
DOI: 10.1016/j.imlet.2013.12.016
发表时间: 2014
期刊: Immunology Letters
影响因子: 4.4
作者: [Yukie Tanaka, Rie Yamazaki, Kiriko Terasako-Saito, Hideki Nakasone, Yu Akahoshi, Hiroshi Nakano, Tomotaka Ugai, Hidenori Wada, Ryoko Yamasaki, Yuko Ishihara, Koji Kawamura, Kana Sakamoto, Masahiro Ashizawa, Miki Sato, Shun-ichi Kimura, Misato Kikuchi, Shi]
通讯作者: Shi
Allotype Analysis to Distinguish the Origin of Varicella-Zoster Virus Immunoglobulin G After Allogeneic Stem Cell Transplantation.
同种异型分析以区分同种异体干细胞移植后水痘带状疱疹病毒免疫球蛋白 G 的起源。
DOI: 10.1016/j.bbmt.2013.04.007
发表时间: 2013
期刊: Biol Blood Marrow Transplant
影响因子: --
作者: [Yamazaki R, Nakasone H, Kanda Y, et al.]
通讯作者: et al.
A study about an environment problem and independence development in remote island and a remote place
  • 批准号:
    11410048
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $8.77万
  • 财政年份:
    1999
  • 负责人:
    KANDA Yoshinobu
  • 依托单位:
海外基金