Selenomethionine protects against neuronal degeneration by methylmercury in the developing rat brain.

硒代蛋氨酸可防止发育中的大鼠大脑中甲基汞引起的神经元变性。

• 批准号: 23510085
• 负责人: SAKAMOTO Mineshi
• 金额: $ 3.41万
• 依托单位: National Institute for Minamata Disease
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23510085/
• 关键词: メチル水銀; セレン; 相互作用; 歯クジラ; 住民; 水俣病; 水俣湾ヘドロ; セレノメチニオン; ラット; 発達期の脳; クジラ; セレノメチオニン

Selenium(Se) is an essential element and may play a role for the protection of MeHg toxicity. We have detected the protective effect of Se against neuronal degeneration induced by MeHg in the developing postnatal rat brain by using a postnatal model rat which is suitable to extrapolate the effects of MeHg in the fetus brain of human (Eco Tox Env Saf 2010). In tooth-whales, MeHg concentrations were positively associated with T-Hg concentrations. However, the MeHg concentrations appeared to reach a plateau. In all species of tooth-whales, Se/I-Hg molar ratio decreased with the increase in T-Hg concentrations, and eventually reached a constant ratio of 1 (Se:I-Hg=1:1). EPMA showed that Hg and Se in the bottlenose dolphin existed in the same place. Hg and Se in blood of inhabitants in a whaling town showed significant and positive correlations in both sexes. The increased Se in blood associated with the Hg level may play a role in protecting against MeHg toxicity in the inhabitants.

硒（Se）是人体必需的元素，对甲基汞的毒性有一定的保护作用。我们使用一种适合推断甲基汞对人类胎儿大脑影响的出生后大鼠模型，检测了硒对发育中的出生后大鼠大脑中甲基汞诱导的神经元变性的保护作用（Eco Tox Env Saf，2010年）。在齿鲸中，甲基汞浓度与总汞浓度呈正相关。然而，甲基汞浓度似乎达到了稳定水平。在所有种类的齿鲸中，Se/I-Hg的摩尔比随着T-Hg浓度的增加而降低，最终达到1（Se：I-Hg=1：1）。电子探针分析表明，汞和硒在海豚体内存在于同一部位。某捕鲸镇居民血汞与血硒呈显著正相关。与汞水平相关的血硒增加可能在保护居民免受甲基汞毒性中起作用。

项目成果

ラット新生仔におけるメチル水銀とセレノメチオニンの毒性に対する相互 防御効果

甲基汞和硒代蛋氨酸对新生大鼠毒性的相互保护作用

• 发表时间: 2011
• 作者: 坂本峰至;安武章;山元恵;Chan HM;柿田明美;近江早苗;小林紗弥香;渡辺 知保
• 通讯作者: 渡辺 知保

Methylmercury exposure and neurological outcomes in Taiji residents accustomed to consuming whale meat

• DOI: 10.1016/j.envint.2014.03.005
• 发表时间: 2014-07-01
• 期刊: ENVIRONMENT INTERNATIONAL
• 影响因子: 11.8
• 作者: Nakamura, Masaald;Hachiya, Noriyuki;Sakamoto, Mineshi
• 通讯作者: Sakamoto, Mineshi

Mercury and DHA levels in maternal and cord blood in relation to segmental maternal hair mercury concentrations at parturition

母体和脐带血中的汞和 DHA 水平与分娩时母体头发汞浓度的关系

• 发表时间: 2012
• 作者: Sakamoto M;Chan HM;Domingo JL;Kawakami S;Murata K
• 通讯作者: Murata K

Increased methylmercury toxicity related to obesity in diabetic KK-Ay mice.

糖尿病 KK-Ay 小鼠中与肥胖相关的甲基汞毒性增加。

• DOI: 10.1002/jat.2954
• 发表时间: 2013
• 期刊: Journal of applied toxicology : JAT.
• 作者: Yamamoto M;Yanagisawa R;Motomura E;Nakamura M;Sakamoto M;Takeya M;Eto K.
• 通讯作者: Eto K.

Recent evidence from epidemiological studies on methylmercury toxicity.

• DOI: 10.1265/jjh.66.682
• 发表时间: 2011-09
• 期刊: Nihon eiseigaku zasshi. Japanese journal of hygiene
• 作者: K. Murata;Minoru Yoshida;M. Sakamoto;Miyuki Iwai-Shimada;Kozue Yaginuma-Sakurai;Nozomi Tatsuta;Toyoto Iwata;K. Karita;Kunihiko Nakai