Development of an organic-inorganic hybrid-type nitric oxide sensor with high selectivity

一氧化氮(NO)在人体内的适宜浓度，与血管的释放、免疫反应等有关，取决于产生它的酶的作用。因此，严重的疾病，如血管硬化和败血症，是由浓度过高引起的。在本研究中，我们着眼于体内的NO浓度，并试图构建一个NO传感系统。金属离子的形式正电荷被认为是由于配位原子的强烈贡献而减少的，从而拒绝进一步的电子补充。这意味着金属离子只能与高活性分子相互作用。对这样一种高NO活性金属分子的改性已被尝试和表征。金属中心不再表现出严格的非选择性，因为金属中心直接作用于电极表面。

Suitable concentration of nitric oxide (NO) in human body, which is concerned with a release of blood vessel, immune response, and so on, depends on the roles of enzymes producing it. So, serious diseases such as hardness of the blood vessel and septicemia are caused by out of the concentration. In this study, we focused on the NO concentration in the body and tried to construct an NO sensing system. Metal ions whose formal positive charge is decreased by strong donation from coordination atoms are thought to refuse further electron supplement. This means that the metal ion can interact only with a highly reactive molecules. Modification of such a high NO reactive metal-containing molecule has been tried and characterized. The metal center did not showed a strict NO selectivity any longer, because the metal center directly interacts on the electrode surface.