Invention of Polymeric Hollow Nanoparticles using Shell-crosslinked Polymer Micelles as Precursors and Their Application

以壳交联聚合物胶束为前驱体的聚合物空心纳米粒子的发明及其应用

• 批准号: 23550248
• 负责人: AKIBA Isamu
• 金额: $ 2.75万
• 依托单位: The University of Kitakyushu
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23550248/
• 关键词: 高分子ミセル; 両親媒性ブロック共重合体; 小角X線散乱; 動的共有結合; 小角X線異常散乱; 制御ラジカル重合; ブロック共重合体

In this study, invention of polymeric hollow nano particles was examined by using shell-crosslinked polymer micelles composed of amphiphilic block copolymers having an alkoxyamine group, which is easily cleaved by heating, between hydrophilic and hydrophobic chains.Small-angle X-ray scattering (SAXS) measurements indicated that shell-crosslinked polymer micelles composed of amphiphilic poly(acrylic acid)-block-polystyrene were successfully prepared. In addition, by heating the aqueous solution of the resulting shell-crosslinked micelles in the presence of large amount toluene, polymeric hollow nano particles were formed due to cleavage of alkoxyamine connections between hydrophobic and hydrophilic chains, and transport of hydrophobic polystyrenes to toluene phase. Therefore, it was concluded shell-crosslinked polymer micelle having alkoxyamine between hydrophobic and hydrophilic chains is an excellent precursor to prepare polymeric hollow nano particles.

本研究利用亲水链和疏水链之间含有烷氧胺基的两亲嵌段共聚物组成的壳交联型聚合物胶束探索了聚合物中空纳米粒子的发明，小角X射线散射(SAXS)测试表明，成功地制备了由两亲性聚丙烯酸-嵌段-聚苯乙烯组成的壳交联型聚合物胶束。此外，在大量甲苯存在的情况下，通过加热壳层交联胶束的水溶液，由于疏水和亲水链之间的烷氧胺连接断裂，疏水聚苯乙烯向甲苯相转移，形成了聚合物中空纳米粒子。因此，在疏水和亲水链之间含有烷氧胺的壳层交联型聚合物胶束是制备聚合物中空纳米粒子的良好前驱体。

项目成果

SAXS、FFF-MALSを用いたAB3型ブロックコポリマーの構造解析

使用 SAXS 和 FFF-MALS 进行 AB3 型嵌段共聚物的结构分析

• 发表时间: 2013
• 作者: 樋岡拓弥;谷尾宣久;新田 恭平 他;坂本俊介,真田雄介,秋葉勇,高田斗志彦,櫻井和朗
• 通讯作者: 坂本俊介,真田雄介,秋葉勇,高田斗志彦,櫻井和朗

Accurate measurements of intrinsic scattering from window materials by use of a vacuum camera

使用真空相机精确测量窗户材料的固有散射

• DOI: 10.1107/s0021889813002628
• 发表时间: 2013
• 期刊: J. Appl. Cryst.,
• 作者: H. Masunaga;K. Sakurai; I. Akiba,K. Ito;M. Takata
• 通讯作者: M. Takata

Anomalous small-angle X-ray scattering study on distribution of low molecular weight compounds encapsulated in polymer micelles

聚合物胶束中低分子化合物分布的反常小角X射线散射研究

• 发表时间: 2013
• 作者: Akiba;I.; Kinoshita;M.; Sanada;Y.; Sakurai;K.
• 通讯作者: K.

69.Anomalous Small-angle X-ray Scattering Study on Aggregation of a Block Copolymer in a Selective Solvent

69.嵌段共聚物在选择性溶剂中聚集的反常小角X射线散射研究

• 发表时间: 2011
• 期刊: Journal of Physics
• 作者: M. Sakou;Y. Shinohara;M. Handa;Y. Amemiya;N. Yagi;H. Masunaga;K. Sakurai;and I. Akiba
• 通讯作者: and I. Akiba

異なる寸水鎖を持つブロック共重合体からなる高分子複合体のpH応答性

不同水链尺寸嵌段共聚物组成的聚合物复合物的pH响应性

• 发表时间: 2014
• 作者: H. O. Lintang;K. Kinbara;T. Yamashita;T. Aida;中島沙理,木下雅貴,秋葉勇
• 通讯作者: 中島沙理,木下雅貴,秋葉勇