Invention of Polymeric Hollow Nanoparticles using Shell-crosslinked Polymer Micelles as Precursors and Their Application

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In this study, invention of polymeric hollow nano particles was examined by using shell-crosslinked polymer micelles composed of amphiphilic block copolymers having an alkoxyamine group, which is easily cleaved by heating, between hydrophilic and hydrophobic chains.Small-angle X-ray scattering (SAXS) measurements indicated that shell-crosslinked polymer micelles composed of amphiphilic poly(acrylic acid)-block-polystyrene were successfully prepared. In addition, by heating the aqueous solution of the resulting shell-crosslinked micelles in the presence of large amount toluene, polymeric hollow nano particles were formed due to cleavage of alkoxyamine connections between hydrophobic and hydrophilic chains, and transport of hydrophobic polystyrenes to toluene phase. Therefore, it was concluded shell-crosslinked polymer micelle having alkoxyamine between hydrophobic and hydrophilic chains is an excellent precursor to prepare polymeric hollow nano particles.