A study on ASP toxin production and dynamics in toxin producing organisms

对产毒硅藻、多系拟菱形藻、轮叶菱形藻和红鳍软骨藻的分布、产毒特性及产毒动态进行了研究。假设N. navis-varingica是一个热带物种，它的分布范围沿着从菲律宾东海岸流向日本的暖水流"黑潮"扩展到日本东部。本文还对白刺的生长特性、毒素谱和遗传标记的地理比较进行了研究。沿着"黑潮"的navis-varingica菌株支持上述假设。n. navis-varingica显示由软骨藻酸和异软骨藻酸A和B组成的毒素谱。研究了影响毒素谱的因素，发现了遗传差异和环境细菌的重要作用。细菌对多系毕赤酵母产毒的影响最明显。

Distribution, ASP toxin production characteristics and the dynamics of these toxins were surveyed for the toxin producing diatom, Pseudo-nitszchia multiseries, Nitzschia navis-varingica and red alga Chondria armata. It was hypothesized that N. navis-varingica is a tropical species and expanded its distribution to eastern Japan along the warm water current "Kuroshio" which flows from the east coast of the Philippines to Japan. The characteristics of growth and the geographical comparison in the toxin profiles and genetic markers in N. navis-varingica strains along the "Kuroshio" supported the above hypothesis. N. navis-varingica shows the toxin profiles composed of domoic acid and isodomoic acids A and B. Factors controlling the toxin profiles were searched, resulting in finding the important roles of genetic difference and environmental bacteria. Bacterial effect on the toxin production seemed to be the most obvious in P. multiseries culture than in other organisms cultures.