Development of novel triterprnoids as a drug candidate that prevent and/or cure for metabolic syndrome related disease.

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It was observed that corosolic acid from residue of apple juice and tubocaposides from the fruit of Tubocapsicum anomalum inhibited the accumulation of triglyceride in adipocyte cell. Tomatidine, which is an aglycone part of tomatine obtained from areal part of Solanum lycopersicum, and pomolic acid isolated from the fruit of Ziziphus jujube suppressed the macrophage foam cell formation. To compare bioactivity, 3-hydroxyl group and 28-carboxylic acid group of ursolic acid was modified. This experiment showed that 28-carboxylic acid group was crucial part to inhibit the macrophage foam cell formation. On the other hands, six triterpenoids having carboxylic acid group were isolated from antler-shaped fruiting body of Ganoderma lucidum. Now these compounds are prepared to examine on foam cell formation in vitro.