Synthesis of new compounds inducing potent and selective differentiation from neural stem cells into neurons

我们合成了一些新的化合物，它们在体外具有从神经元祖细胞向神经元的选择性分化活性。结果表明，在ω-末端引入间甲基苯基的维生素K类似物具有最强的活性，是对照的两倍。这一发现表明，通过对维生素K进行修饰，将有可能获得更有效的化合物。现在我们将研究这些化合物的作用机制。

We synthesized new compounds, which have selective differentiation activity from neuronal progenitor cells into neurons in vitro. The result of the assay exhibited vitamin K analogues introduced m-methylphenyl group at the omega-terminal position had the most potent activity, which was twice as much as control. This finding indicated that it will be possible to obtain much more potent compounds with modification of vitamin K. Now we are going to investigate the functional mechanism of the compounds.