Characterization of Radiation-modified Hydrogel based on Methylcellulose, Hydroxypropylcellulose and Hydroxypropylmethylcellulose

周围神经病变是由高剂量和多剂量细胞毒性药物引起的有害药物不良反应。在本研究中，我们着重于水凝胶作为口服给药的替代方案。研究了电子束辐照制备的水凝胶的理化性质及其作为药物载体的可行性。将10%或20%的甲基纤维素、羟丙基纤维素或羟丙基甲基纤维素的水溶液照射至10至50 kGy的剂量以获得凝胶。各样品凝胶含量随剂量的增加而增加。相反，肿胀程度随剂量的增加而降低。水凝胶的凝胶强度随聚合物含量和用量的增加而提高。由此可见，利用电子束辐射制备水凝胶是可行的，作为药物载体是可行的。

Peripheral neuropathy is a harmful adverse drug reaction induced by high and multiple dosing of cytotoxic drugs. In this study, we focused on the hydrogel as an alternative for the oral administration.The goal of this study was to investigate the physicochemical properties of hydrogel prepared by electron beam irradiation and the feasibility as a drug carrier. Aqueous solution of 10 or 20 wt% methylcellulose, hydroxypropylcellulose or hydroxypropyl methylcellulose were irradiated to a dose of 10 to 50 kGy to obtain gels.Gel fraction of each sample increased with increase in the dose. In contrast, the degree of swelling decreased with increase in the dose. Gel strength of hydrogels was improved with increasing polymer content and the dose. From these results, the hydrogels could be obtained by the electron beam radiation, and it seemed to be feasible as a drug carrier.