Characterization of Radiation-modified Hydrogel based on Methylcellulose, Hydroxypropylcellulose and Hydroxypropylmethylcellulose

周围神经病是大剂量、多剂量细胞毒药物引起的一种有害的药物不良反应。本研究以水凝胶为研究对象，研究电子束辐照制备的水凝胶的理化性质及其作为药物载体的可行性。将10或20wt%的甲基纤维素、羟丙基纤维素或羟丙基甲基纤维素的水溶液以10~50kGy射线照射，得到凝胶，每个样品的凝胶分数随着剂量的增加而增加。相反，溶胀度随剂量的增加而降低。水凝胶的凝胶强度随聚合物含量的增加和剂量的增加而提高。这些结果表明，电子束辐照可以得到水凝胶，作为药物载体是可行的。

Peripheral neuropathy is a harmful adverse drug reaction induced by high and multiple dosing of cytotoxic drugs. In this study, we focused on the hydrogel as an alternative for the oral administration.The goal of this study was to investigate the physicochemical properties of hydrogel prepared by electron beam irradiation and the feasibility as a drug carrier. Aqueous solution of 10 or 20 wt% methylcellulose, hydroxypropylcellulose or hydroxypropyl methylcellulose were irradiated to a dose of 10 to 50 kGy to obtain gels.Gel fraction of each sample increased with increase in the dose. In contrast, the degree of swelling decreased with increase in the dose. Gel strength of hydrogels was improved with increasing polymer content and the dose. From these results, the hydrogels could be obtained by the electron beam radiation, and it seemed to be feasible as a drug carrier.