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Analysis of the epithelial-mesenchymal transition (EMT) mechanism by utilizing neural crest cell generation model.

Analysis of the epithelial-mesenchymal transition (EMT) mechanism by utilizing neural crest cell generation model.
利用神经嵴细胞生成模型分析上皮间质转化(EMT)机制。
批准号:
23590233
负责人:
MOTOHASHI Tsutomu
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
We identified the up-regulated genes in epithelial-mesenchymal transition (EMT) by utilizing the embryonic stem cells and mice, where the expression of Sox10 can be visualized with a fluorescent protein. Among these genes, we found the transcription factors that enhanced EMT. In addition, we found that glycoprotein Galectin-1 enhanced neural crest cell generation.
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Gene expression analysis of Neural crest cells in their early developmental stage
早期发育阶段神经嵴细胞的基因表达分析
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Daisuke Kitagawa, Tsutomu Motohashi]
通讯作者: Tsutomu Motohashi
Notch signal play a role in the multipotency of melanoblast
Notch信号在黑素细胞的多能性中发挥作用
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [渡邉奈月, 本橋力]
通讯作者: 本橋力
色素芽細胞の持つ多分化能にNotchシグナルが重要である
Notch信号对于成色细胞的多能性很重要
DOI: --
发表时间:
期刊:
影响因子: --
作者: [渡邉奈月, 西岡真弘, 若岡敬紀, 広部知久, 本橋 力, 國貞隆弘]
通讯作者: 國貞隆弘
Novel genes of neural crest cells generation elucidated by gene expression analysis
通过基因表达分析阐明神经嵴细胞生成的新基因
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Kawakami, K., Ikeda, K., Sugimoto, H., 池田啓子, Inamura N et al., Tsutomu Motohashi]
通讯作者: Tsutomu Motohashi
18
    Analysis of Epithelial-Mesenchymal Transition (EMT) Mechanism by using EMT model system.
    • 批准号:
      26460273
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2014
    • 负责人:
      MOTOHASHI Tsutomu
    • 依托单位:
    Establishment of the neurocristopathy treatment model and analysis of the differentiation mechanism of neural crest cells using mouse embryonic stem cells.
    • 批准号:
      20592086
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2008
    • 负责人:
      MOTOHASHI Tsutomu
    • 依托单位:
    Analysis of generation and differentiation of neural crest cells derived from mouse embryonic stem cells
    • 批准号:
      18591952
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.53万
    • 财政年份:
      2006
    • 负责人:
      MOTOHASHI Tsutomu
    • 依托单位:
    海外基金