Analysis of the epithelial-mesenchymal transition (EMT) mechanism by utilizing neural crest cell generation model.
Analysis of the epithelial-mesenchymal transition (EMT) mechanism by utilizing neural crest cell generation model.
批准号:
23590233
负责人:
MOTOHASHI Tsutomu
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
We identified the up-regulated genes in epithelial-mesenchymal transition (EMT) by utilizing the embryonic stem cells and mice, where the expression of Sox10 can be visualized with a fluorescent protein. Among these genes, we found the transcription factors that enhanced EMT. In addition, we found that glycoprotein Galectin-1 enhanced neural crest cell generation.
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Gene expression analysis of Neural crest cells in their early developmental stage
早期发育阶段神经嵴细胞的基因表达分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Daisuke Kitagawa, Tsutomu Motohashi]
通讯作者:
Tsutomu Motohashi
Notch signal play a role in the multipotency of melanoblast
Notch信号在黑素细胞的多能性中发挥作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[渡邉奈月, 本橋力]
通讯作者:
本橋力
色素芽細胞の持つ多分化能にNotchシグナルが重要である
Notch信号对于成色细胞的多能性很重要
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[渡邉奈月, 西岡真弘, 若岡敬紀, 広部知久, 本橋 力, 國貞隆弘]
通讯作者:
國貞隆弘
Novel genes of neural crest cells generation elucidated by gene expression analysis
通过基因表达分析阐明神经嵴细胞生成的新基因
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kawakami, K., Ikeda, K., Sugimoto, H., 池田啓子, Inamura N et al., Tsutomu Motohashi]
通讯作者:
Tsutomu Motohashi
Novel genes of neural crest cells generation elucidated by gene expression analysis.
通过基因表达分析阐明神经嵴细胞生成的新基因。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Tsutomu Motohashi, Daisuke Kitagawa, Takanori Wakaoka, Natsuki Watanabe, Takahiro Kunisada]
通讯作者:
Takahiro Kunisada
共 18 条
Analysis of Epithelial-Mesenchymal Transition (EMT) Mechanism by using EMT model system.
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批准号:26460273
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2014
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负责人:MOTOHASHI Tsutomu
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依托单位:
Establishment of the neurocristopathy treatment model and analysis of the differentiation mechanism of neural crest cells using mouse embryonic stem cells.
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批准号:20592086
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2008
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负责人:MOTOHASHI Tsutomu
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依托单位:
Analysis of generation and differentiation of neural crest cells derived from mouse embryonic stem cells
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批准号:18591952
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.53万
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财政年份:2006
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负责人:MOTOHASHI Tsutomu
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依托单位:
海外基金