Establishment of the neurocristopathy treatment model and analysis of the differentiation mechanism of neural crest cells using mouse embryonic stem cells.

点击翻译按钮获取中文摘要

For the purpose of elucidating the mechanism of the neural crest cell differentiation, we generated the embryonic stem cells and mice, where the expression of Sox10 can be visualized with a fluorescent protein. The transplanted neural crest cells derived from the ES cells survived in the embryonic intestinal tract. We separated neural crest cells from the gene modified embryo and analyzed the gene expression by gene arrays. In addition, using the mice, we found that the multipotent neural crest-like cells were maintained in skin.