Roles of skin sympathetic nerve activity synchronized with cardiac cycle in baroreflex control of skin blood flow in hyperthermic humans

皮肤交感神经活动与心动周期同步在高温人体皮肤血流压力反射控制中的作用

• 批准号: 23590277
• 负责人: KAMIJO Yoshi-ichiro
• 金额: $ 3.41万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590277/
• 关键词: 温熱生理学; 皮膚血流; 暑熱負荷; 皮膚交感神経活動; 圧受容器; 心周期; 心周期同期成分; 圧受容器反射; 高体温; 静脈還流量; 皮膚交感神経活動・心周期同期成分; 圧反射性皮膚血流調節

Body temperature in humans is controlled by heat dissipation due to large amounts of skin blood flow and sweat in the hot. However, since blood pooling in skin vessels in an upright position and hypovolemia due to sweat loss decrease venous return to the heart, it threatens blood pressure maintenance. To prevent this, skin vasodilation is suppressed through baroreflexes. Recently, we suggested that a component of skin sympathetic nerve activity (SSNA) synchronized with cardiac cycle was an efferent path of the baroreflex control of skin blood flow; however, it might contain muscle sympathetic nerve activity (MSNA). Here, we found in hyperthermic men that the SSNA component decreased while MSNA increased with head-up tilt. Thus, the component unlikely contains MSNA.

人体的体温是由热量散失控制的，因为皮肤在高温下有大量的血液流动和汗液。然而，由于直立体位时皮肤血管中的血液淤积和因失汗引起的低血容量减少了静脉回流到心脏，这威胁到血压的维持。为了防止这种情况，通过压力反射抑制皮肤血管舒张。最近，我们提出了与心脏周期同步的皮肤交感神经活动（SSNA）的一个组成部分是皮肤血流的气压反射控制的传出途径；然而，它可能包含肌肉交感神经活动（MSNA）。在这里，我们发现在体温过高的男性中，随着头部向上倾斜，SSNA成分减少，而MSNA成分增加。因此，该组件不太可能包含MSNA。

项目成果

Exercise training based on individual physical fitness and interval walking training to prevent lifestyle-related diseases in middle-aged and older people

基于个体体质的运动训练和间歇步行训练预防中老年人生活方式相关疾病

• 发表时间: 2012
• 期刊: J Phys F itness Sports Med
• 作者: Nose H;Morikawa M;Masuki S;Miyagawa K;Kamijo Y;Gen-no H
• 通讯作者: Gen-no H

Head-up tilt suppressed sympathetic nerve activity synchronized with cardiac cycle to skin but increased that to muscle in passively warmed men.

在被动保暖的男性中，抬头倾斜会抑制与心动周期同步的皮肤交感神经活动，但会增加肌肉的交感神经活动。

• 发表时间: 2013
• 作者: Ogawa Y;Kamijo Y;Ikegawa S;Masuki S;Morita A;and Nose H
• 通讯作者: and Nose H

Skin sympathetic nerve activity component synchronized with cardiac cycle is involved in hyperosmotic suppression of cutaneous vasodilation in hyperthermia

与心动周期同步的皮肤交感神经活动成分参与热疗时皮肤血管舒张的高渗抑制

• 发表时间: 2012
• 作者: Kamijo Y;Okada Y;Ikegawa S;Okazaki K;Goto M;and Nose H
• 通讯作者: and Nose H

Skin sympathetic nerve activity component synchronizing with cardiac cycle is involved in hypovolaemic suppression of cutaneous vasodilatation in hyperthermia

• DOI: 10.1113/jphysiol.2011.220251
• 发表时间: 2011-12-01
• 期刊: JOURNAL OF PHYSIOLOGY-LONDON
• 影响因子: 5.5
• 作者: Kamijo, Yoshi-ichiro;Okada, Yoshiyuki;Nose, Hiroshi
• 通讯作者: Nose, Hiroshi

Rapid plasma volume restoration increased skin sympathetic nerve activity component synchronized with cardiac cycle and cutaneous vasodilation in hypovolemic and passively warmed men

快速血浆容量恢复增加了低血容量和被动保暖男性的皮肤交感神经活动成分，与心动周期和皮肤血管舒张同步

• 发表时间: 2013
• 作者: Kamijo Y;Okazaki K;Ikegawa S;Okada Y;and Nose H
• 通讯作者: and Nose H